Substituted Methyl Benzimidazole Carbamate (CDRI Compound 81-470) in the Mass Treatment of Poultry Round Worms

概要

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Methyl 5 [4- (2-pyridinyl) -1- piperazinylcarbonyl] -1-H- benzimidazol -2- yl carbamate: (CDRI Comp. 81/470) has consistently exhibited broadspectrum anthelmintic efficacy both against adult and larval stages of various helminth parasites of experimental and domestic animals by oral or parenteral route. The compound incorporated in transdermal tape has also yielded anthelmintic action. In order to increase solubility and to make mass administration easier, two formulations e.g. soluble and dispersible, were prepared and found effective in control testing against various helminth parasites of rodents. Both the preparations were put to trial at 3 dose schedules to ascertain their utility for mass treatment of poultry carrying Ascaridia galli infection. Though the three dose schedule (20mg/kgx1, 10mg/kgx2, 5mg/kgx3 days) were found to have parallel efficacy, 5mg/kgx3 days dose requiring lesser compound than single administration was suggested useful in mass therapy. Thus, either of the preparations could be safely used for the control of poultry round-worms. However, the dispersible formulation having longer shelf-life and convenience of packaging and transportation may be preferred over the soluble preparation.
長崎大学の論文