Anthelmintic Efficacy of Soluble Formulation of A Benzimidazole Carbamate A Broad Spectrum Anthelmintic

スポンサーリンク

概要

• 論文の詳細を見る

• Methyl-[5-{(4-(2-pyridinyl)-1-piperazinyl)-carbonyl}-1H-benzimidazol-2-yl]-carbamate (CDRI Compound 81/470) has consistently exhibited broad-spectrum anthelmintic efficacy both against adult and larval stages of various helminth parasites of experimental and domestic animals, by oral and parenteral routes. The compound incorporated in transdermal tapes has also yielded anthelmintic action. With a view to enhance absorption and consequently the efficacy, a soluble formulation of the compound has been developed and its efficacy was evaluated against various experimental helminth parasites of rodents (Ancylostoma ceylanicum (adult), Nippostrongylus brasiliensis (adult and L_4), Syphacia obvelata (adult)) and poultry (Ascaridia galli). This appears to be the only benzimidazole which could be solubilized. While the soluble formulation has been found to have comparable efficacy to the powder form against intestinal worms, the efficacy was substantially increased against systemic parasites (N. brasiliensis L_4 stage). The enhanced efficacy by oral route is very well correlated with high absorption of drug from soluble formulation which has been demonstrated by the pharmacokinetic studies reported by Nagaraja et al. (1995). The results of the present study suggest that the soluble formulation may find wider application in respect to easy administration through drinking water in large herds, flocks and also against tissue dwelling parasites specially filarids.

• 長崎大学の論文

著者

• Gupta S

  Central Drug Res. Inst. Lucknow Ind

• Suman Gupta

  Division of Parasitology, Central Drug Research Institute Lucknow

• Suman Gupta

  Division Of Parasitology Central Drug Research Institute Lucknow-226001 India

• Singh S.

  Division Of Pharmacology Indian Institute Of Integrative Medicine Csir

• Gupta Suman

  Division of Parasitology, Central Drug Research Institute, Lucknow-226001 India

• Jain G.

  Division of Pharmaceutics, Central Drug Research Institute, Lucknow

関連論文

• Anthelmintic Efficacy of Soluble Formulation of A Benzimidazole Carbamate A Broad Spectrum Anthelmintic
• Anilino-(2-Bromophenyl) Acetonitrile and Their Analogues as Orally Effective Antileishmanial Agents
• Simultaneous high-performance liquid chromatographic determination of Cedrus deodara active constituents and their pharmacokinetic profile in mice
• Substituted Methyl Benzimidazole Carbamate (CDRI Compound 81-470) in the Mass Treatment of Poultry Round Worms
• Direct Agglutination Test Based on Freeze Dried Antigen from Leishmania donovani : Development and Comparative Evaluation with Aqueous Antigen and Recombinant rK_ Antigen for Sero-diagnosis of Visceral Leishmaniasis

スポンサーリンク