幼駒パラチフス症の臨床竝びに血液學的觀察特にその診斷的意義について
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概要
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The authors tried to investigate the behavior of 8 foals against the infection with abortion bacilli throughout the course of the diseases. All foals which were perrorally inoculated with a very minute does of living Salmonella abortus-equi such as 7.3 millions, revealed the symptoms of infection. One out of 8 foals died of septicemia at 13 days after inoculation. It seemed to us that the symptoms of these artificial infected animals were same as in the natural cases. In the present paper some clinical and haematological observations on each inoculated cases throughout the course are described. The results are summarized as follows : 1) One foal revealed the rise of temperature at 3 days after inoculation, 1 took 4 days, 5 took 5∿8 days and the other 1 took 10 days (Fig. 1). 2) The types of fever were roughly divided into following two groups : One group showed continued fever at the first attack of fever and then turned to irregular fever after the crisis. The other turned to irregular fever after the ephemeral fever. These irregular fever usually continued for considerable long time (Fig. 1). 3) The rise of the attacked fever was relatively slight and did not rise over 40℃. When a fever manifests the irregular type, the difference of temperature in the morning and evening is large and the largest is 2.5℃. 4) The inc rease and decrease of leucocytes-number was the chief haematological manifestation of this disease. This change was roughly divided into following two groups. One group showed leucopenia at the first attack of fever, and when the temperature became normal, it turned to leucocytosis and turned to normal. The other showed leucocytosis at the attack of fever, and then turned to normal gradually after the crisis (Fig. 1). 5) The nucleus-shift of leucocytes was very important manifestation as well as the rise and fall of leucocyte number. We observed in all foals the decrease of nucleas segmentation of leucocytes (shift to the left) before the first attack of fever. Some of them turned to normal after the crisis and the other showed shift to the left while the irregular fever continued (Fig. 1,Table. 2). As mentioned above, there are different clinical and haematological types of the Paratyphoid in foals. The chief manifestations of this disease was the fever and changes of leucocytes, however, these changes alone are not to be accepted as special changes of the Paratyphoid. On the other hand, the agglutination reaction is the most widely used method of diagnosis, however, the interpretation of the agglutinin titre is not always easy especially when the titre is intermediate as 1 : 800-1 : 1600. In these cases it demands a knowledge of the clinical symptoms and hae matological changes. A titre of 1 : 800 or over in the presence of pyrexia and nucleus shift to the left is very suggestive of active infection with S. abortus-equi.
- 北海道大学の論文