Potentiation of antitumor effect of NKT cell ligand,′ α-galctosylceramide by combination with IL-12 on lung′ metastasis of malignant melanoma cells.
スポンサーリンク
概要
著者
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Kawano T.
CREST Project and Dept.Mol.Immunol.,′ Grad.Sch. Med., Chiba Univ.
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′ Taniguchi
CREST Project and Dept. Mol.′ Immunol., Grad.Sch.Med., Chiba Univ.
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Nakui M.
Section Of Genetic Engineering Research Center For Genetic′ Engineering And Cell Transplantation And
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Iwakabe K.
′ Section Of Genetic Engineering Research Center For Genetic′ Engineering And Cell Transplantation T
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Ohta A.
Section of Genetic Engineering, Research Center′ for Genetic Engineering and Cell Transplantation, T
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Kitamura H.
Section of Genetic′ Engineering, Research Center for Genetic Engineering and′ Cell Transplantation,
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Sato M.
Section of Genetic′ Engineering, Research Center for Genetic Engineering and′ Cell Transplantation,
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Nishimura T.
Section of Genetic′ Engineering, Research Center for Genetic Engineering and′ Cell Transplantation,
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Sekimoto M.
Section Of Genetic′ Engineering Research Center For Genetic Engineering And Cell′ Transplantation To
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Koda T.
Division of′ Immunoregulation, Institute for Genetic Medicine, Hokkaido′ University
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′ Yahata
Section of Genetic Engineering, Research Center′ for Genetic Engineering and Cell Transplantation, T
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Makuuchi H.
Department of′ Surgery, Tokai University School of Medicine
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Takeda K.
Division′ Of Immunoregulation Institute For Genetic Medicine Hokkaido′ University
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′ Yahata
Section Of Genetic Engineering Research Center′ For Genetic Engineering And Cell Transplantation Tok
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Nishimura T.
Section Of Genetic′ Engineering Research Center For Genetic Engineering And Cell′ Transplantation To
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Kitamura H.
Section Of Genetic′ Engineering Research Center For Genetic Engineering And Cell′ Transplantation To
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Ohta A.
Section of′ Genetic Engineering, Research Center for Genetic Engineering′ and Cell Transplantation, Tokai University School of Medicine′ and Division of Immunoregulation, Institute for Genetic′ Medicine, Hokkaido University
関連論文
- The interface between innate and acquired immunity: glycolipid′ antigen presentation by CD1d-expressing dendritic cells to′ NKT cells induces the differentiation of antigen-specific′ cytotoxic T lymphocytes.
- The essential role of phorbol ester-sensitive protein kinase C′ isoforms in activation-induced cell death of Th1 cells.
- The quantitative and qualitative defect of CD4+CD45RO+′ memory-type T cells are involved in the abnormality of TH1′ immunity in atopic dermatitis patients.
- The critical role of Th1-dominant immunity in tumor′ immunology.
- Functional heterogeneity among bone marrow-derived dendritic′ cells conditioned by Th1- and Th2-biasing cytokines for the′ generation of allogeneic cytotoxic T lymphocytes.
- Potentiation of antitumor effect of NKT cell ligand,′ α-galctosylceramide by combination with IL-12 on lung′ metastasis of malignant melanoma cells.
- Distinct role of antigen-specific T helper type 1 (Th1) and Th2′ cells in tumor eradication in vivo.
- The natural killer T (NKT) cell ligand _-galactosylceramide′ demonstrates its immunopotentiating effect by inducing′ intreleukin (IL)-12 production by dendritic cells and IL-12′ receptor expression on NKT cells.
- Indispensable role for TNF-α and IFN-γ at the effector′ phase of liver injury mediated by Th1 cells specific to′ hepatitis B virus surface antigen.