<原著>子宮頸部異形成の悪性化とヒトパピローマウイルス感染

概要

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Previous follow-up data have shown that most cervical carcinoma had progressed from cervical dysplasia. Recently, molecular biological studies have suggested the association between human papilloma virus (HPV) 16 and 18 type and cervical carcinoma. To prove the natural history of HPV 16 and 18 type in cervical lesions, we examined formalin-fixed, paraffin-embedded surgical and biopsy specimens of dysplasia, for the presence of HPV16/18. The dysplasia cases were classified into showing progression to carcinoma (progressive group), recurrence (persistant group) and spontaneous regression (regression group). HPV16/18DNA were detected in 13/26 (50%) of the progressive group. HPV16/18DNA was not detected in any of the 16 cases and 3 cases of the regression and persistant groups, respectively. Of the 8 cases which had progressed to carcinoma in situ (CIS), 2 cases had HPVl6/18DNA only at the stage of dysplasia and no HPV DNA at the stage of carcinoma. However, of 5 cases which had progressed to invasive carcinoma, 2 cases constantly had HPV16/18DNA throughout the stage from dysplasia to invasive carcinoma. This retrospective study indicates that dysplasia with HPV16/18DNA may progress to carcinoma.
近畿大学の論文
1992-06-25