<原著>ニュージーランドマウス(NZB/WF_1)の腎障害に対するグリチルリチンの作用

概要

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The effects of glychrrhizin (Gly.) and dexamethazone (Dexa.) and the combination of the two drugs on the development of renal disease and survival in female NZB/WF_1 mice were examined. The mice were treated with Gly. (dose 20 mg/kg of body weight) or Dexa. (dose 1.0 mg/kg of body weight) or a combination of the two drugs twice a week. These treatments were started at 4 weeks old and 20 weeks old. Control mice were given saline. Body weight and proteinuria were measured every two weeks and renal histology, hemolytic test (against sheep red blood cells) and the number of plaque forming cells were observed at 8 months old. When these treatments were started at 4 weeks old, the survival time was 314 days in Gly. -treated mice, 351 days in Dexa. -treated mice, 378 days in mice treated with both drugs and 263 days in untreated control mice. Survival time was prolonged similarly in Gly. -treated mice and in mice treated with Gly. and Dexa. starting at 20 weeks old. Administrations of Gly., Dexa., or both drugs protected NZB/WF_1 mice from the development of glomerulonephritis and the combination therapy of the two drugs was the most effective. These results indicate that the use of Gly. alone or the combination of Gly. and a steroid might be valuable against autoimmune diseases.
1991-12-25