<原著>意識下犬における全幹迷切前後の膵外分泌機能と消化管ホルモン動態に関する研究

概要

論文の詳細を見る
The pancreatic exocrine function and gut hormonal response were examined before and after truncal vagotomy in 6 conscious dogs with chronic pancreatic and gastric fistula. The volume of pancreatic juice, bicarbonate, protein, and amylase outputs in pancreatic juice, and simultaneously peripheral blood secretin and cholecystokinin (CCK) concentrations were measured in the conscious state every 15 minutes under the following state ; 1) foods, 2) continuous intraduodenal infusion of sodium oleate (pH 9.0,8.5 mmol/l), and 3) continuous intraveous infusion of secretin (1 u/kg/h). The total truncal vagotomy markedlly decreased the volume of pancreatic juice, pancreatic bicarbonate secretion, protein secretion, and amylase secretion during foods and intraduodenal administration of oleate as internal pancreatic stimulating tests, and also decreased during intraveous administration of secretin as external pancreatic stimulating tests. Total truncal vagotomy did not affect the release of plasma secretin during internal pancreatic stimulating tests, or the release of plasma CCK during internal and external pancreatic stimulating tests. These findings demonstrate that truncal vagotomy inhibits pancreatic exocrine function in response to foods, fat and secretin, but does not interfere with the release of secretin and CCK. The effects may be due to interruption of the vagus-mediated reflex between the intestine and the pancreas.
近畿大学の論文
1990-09-25