<原著>胃癌原発巣および転移巣におけるlamininの免疫組織学的研究
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An immunohistological study of laminin in gastric cancers was performed. The mode of location of laminin and further the relations with the histological type and hepatic metastasis were also examined. The materials were obtained from gastric cancers removed from 231 patients and formalin-fixed paraffin sections were prepared. An immunohistological stain was performed with rabbit anti-human laminin antibody as the primary antibody and by the ABC method. The rate of response positive for laminin (the positive response rate) of the whole gastric cancer was 23.4%. According to histological type, the positive response rate was 46.7% for well differentiated adenocarcinomas, 29.3% for moderately differentiated ones and only 13.0% for poorly differentiated ones, the higher the degree of differentiation, the higher the rate (p<0.01). When poorly differentiated adenocarcinomas were classified newly into solid, medullary and scirrhous types, all the 6 laminin-positive cases were of the solid type. The positive response rate was 14.7% in cases without hepatic metastasis, 88.9% in cases complicated with hepatic metastasis and 91.7% for hepatic metastatic lesions, the rate being higher in cases of hepatic metastasis (p<0.001). In poorly differentiated adenocarcinomas in particular 3 out of 4 cases complicated with hepatic metastasis were positive for laminin and were of the solid type. As the result, laminin-positive cancers showed hematogenous metastasis by participating in the mass formation of cancer cells and in the attachment of the cancer cells to the basement membrane in the target organs during the process of hematogenous metastasis. It is further suggested that the conventional relation between the histological type and hepatic metastasis can be supported from the standpoint of laminin stain.
- 近畿大学の論文
- 1989-09-25
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