<原著>Muramyl dipeptide誘導体のヒト顆粒球・マクロファージ系造血に及ぼす影響

概要

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The effects of the muramyl dipeptide (MDP)-Lys(L18), a MDP analog, on colony-stimulating factor (CSF) production in human peripheral blood mononuclear cell (PMNC) cultures and bone marrow granulocytic progenitor cells (CFU-C) were investigated using in vitro clonal culture assay. MDP-Lys(L18) did not act as a CSF, but increased CSF production in the supernatant of phytohemagglutinin (PHA)-stimulated PMNC cultures. This effect of MDP-Lys(L18) influenced in adherent cells. MDP-Lys(L18) induced an increase in the number of colonies formed with bone marrow CFU-C, especially in the macrophagic colony, in the presence of CSF. The production of interleukin 1,however, was also increased in PMNC cultures when MDP-Lys(L18) was used alone. On the other hand, the PHA-induced interleukin 2 production, of PMNC cultures in vitro, was inhibited by MDP-Lys(L18). These results suggest that MDP-Lys(L18) may alleviate the leukopenia that occurs in patients receiving chemotherapy.
近畿大学の論文
1989-06-25