<原著>大腸癌原発巣と肝転移巣におけるlamininの局在に関する免疫組織学的検討

概要

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In 143 colo-rectal cancer and 14 liver metastatic lesions, the localization of laminin (a glycoprotein of basement membrane) was investigated immunohistochemically using avidin biotin immunocomplex (ABC) method and the involvement of laminin in the metastasis was also examined. In normal epithelium, laminin was visualized in the basement membrane, and the positive rate in primary cancer was 32/143 (22.4%). In the primary lesions with and without liver metastasis these rates were 15/29 (51.7%) and 17/114 (14.9%), respectively, while in liver metastatic lesions it was found as high as 11/14 (78.6%). Thus, laminin may play a great part in development of metastasis, especially the depositing of tumor cells in the target organs. In an attempt to correlate liver metastatic rate with the positive rate of laminin, the depth of infiltration, and the degree of venous invasion in the primary lesions, the laminin negative lesions with low degree of venous invasion had liver metastatic rate of 9/29 (31.0%), and the positive ones with high degree, 6/9 (66.7%). In all stages of the depth of invasion, the laminin positive lesions had higher liver metastatic rate than the negative lesions. From these results, immunohistochemical staining of laminin may be a useful procedure as to predict a possibility of liver metastasis in colo-rectal cancer.
近畿大学の論文
1989-06-25