<原著>本幹迷走神経切除の血中脂質および胆汁成分に及ぼす実験的研究
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It has been suggested that operation on the stomach may encourage the subsequent development of gall stones. Since experimental evidence suggests that vagotomy may impair biliary metabolism, this may provide a possible link between gastric surgery and frequent subsequent disorders. The aim of this present investigation is to ascertain the occurance of gall stones following truncal vagotomy. Using male adult mongrel dogs (weighing 12-16 kg), under intravenous pentobarbital (20-30 mg/kg) anesthesia, truncal vagotomy with Heineke-Mikulicz pyloroplasty was performed. Before truncal vagotomy, bile was drawn from the gallbladder after laparotomy and peripheral blood was taken from the saphenous vein of the dogs. 14Fr. size rubber tubes were placed into and fixed to the gallbladder leading out of the back of the dogs. The bile composition and peripheral blood content was determined at intervals 1st, 2nd, 3rd and 4th week after the truncal vagotomy. As a control group, a sham operation was made by laparotomy and a drainage tube was fixed to the gallbladder leading out of the back of dogs. The following chemicals were measured pre and post of this experiment, serum cholesterol, phospholipid, bile salts, GOT, GPT, triglyceride, total bilirubin and bile cholesterol, bile phospholipid and bile salts in the two groups of truncal vagotomy and truncal vagotomy plus intravenous hyperalimentation. Cholecystokinin was also determined in these two groups. The concentration of serum cholesterol showed a significant rise 1st, 3rd and 4th week after truncal vagotomy (P<0.05). The concentration of serum phospholipid showed a significant rise 2nd, 3rd and 4th week after truncal vagotomy. The concentration of serum bile salts showed a significant reduction one week after truncal vagotomy. The concentration of bile cholesterol showed no significant rise after truncal vagotomy but in the relative concentration of phospholipid, cholesterol and bile salts, a significant rise 1st, 2nd, 3rd and 4th week after truncal vagotomy was observed. In the group of truncal vagotomy plus intravenous hyperalimentation, serum cholesterol showed an insignificant rise. The concentration of serum phospholipid showed a slight rise 1st, 2nd and 3rd week after truncal vagotomy. The concentration of serum bile salts showed a slight rise after truncal vagotomy. In the group of truncal vagotomy plus intravenous hyperalimentation, the relative concentration of bile cholesterol showed an insignificant rise after truncal vagotomy but a significant rise 4 weeks after truncal vagotomy. The relative concentration of phospholipid showed a slight rise after truncal vagotomy. The relative concentration of bile salt showed a slight reduction after truncal vagotomy. The lithogenic tendency in the bile was similar in the truncal vagotomy plus intravenous hyperalimentation group and in the truncal vagotomy group.
- 近畿大学の論文
- 1987-09-25
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