<原著>制癌剤感受性ならびに化学療法効果の予知に関する基礎的研究 : flow cytometryおよび細胞診によるアプローチ

概要

論文の詳細を見る
For the fundamental study on the assessment of chemotherapy sensitivity by means of cytologic examinations and flow cytometry, in vitro and in vivo investigations were made on the morphological changes and cell cycle of L-1210 (cultured cells of mouse leukemia) after administration of various anticancer drugs. Among nine drugs investigated, namely, aclacinomycin-A, adriamycin, bleomycin, peplomycin, actinomycin-D, mitomycin-C, neocarzinostatin, cisplatin and 5-Fu, of three drugs, adriamycin, neocarzinostatin and cisplatin, it was considered to be possible to predict the chemotherapy sensitivity by cytologic examinations. On the other hand, when the diversity of nuclear DNA histogram after administration of the anticancer drugs was investigated by flow cytometry, it was considered that the chemotherapy sensitivity of all the nine drugs could be predicted by those changes and that the flow cytometric analysis of nuclear DNA content provided clinically important information on the assessment of chemotherapy sensitivity so far as tumors are monoclonal and easy to analyze for nuclear DNA histogram.
近畿大学の論文
1985-09-25