<原著>坐骨神経切断犬におけるsuccinylcholineによる高カリウム血症に及ぼすlidocaineの影響

概要

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The effects of lidocaine on the potassium efflux from normal and denervated legs were investigated. Unilateral sciatic section, right or left, was performed in dogs. Then, 22 to 25 days later the dogs were anesthetized with pentobarbital, the trachea was intubated, and the lungs were ventilated mechanically. Catheters were placed in both femoral veins and the venous blood was sampled respectively. The responses of normal and denervated legs to succinylcholine were compared and the effects of prior administration of lidocaine on the changes of serum potassium level were examined. The following results were obtained. 1. 10mg/kg of lidocaine attenuated hyperkalemic response. 2. 20mg/kg of lidocaine blocked potassium efflux but not completely. 3. 30mg/kg lidocaine completely blocked succinylcholine-induced potassium efflux.
近畿大学の論文
1978-12-25