<原著>糖尿病生検筋の光顕的および電顕的研究 : 特に"Diabetic amyotrophy"と通常の糖尿病例との比較を中心として

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The authors examined muscle biopsies from three cases of diabetes mellitus in order to compare morphological characteristics of diabetic amyotrophy to the one which did not show muscle atrophy. Clinical characteristics of the cases were diabetic amyotrophy in case No.1,42 years old male, diabetes mellitus without any sign of muscle disorders and neuropathy in case No.2,48 years old male, and diabetes mellitus with severe neuropathy. Muscle biopsies were from vastus in case No.1 and 2,and peroneus in case No.3. Histological, light and electron microscopic examinations revealed various findings in all cases and 1ed us to the following conclusive remarks. 1) Various morphologic findings of our cases are the same as the one which has been reported in many references being concerned to diabetic amyotrophy except for the changes in ultrastructure ; "sarcoplasmic mass" in case No.1 and "concentric laminated bodies" in case No.2. 2) None of characteristic findings in the case No.1 can be designated in comparison with the other cases. 3) By means of histogram not only the case No.1 but also the case No.2 and 3 showed remarkable atrophy of type 1,2A and 2B fibers. Type 2 fibers were more marked than type 1 in the degree of atrophy. Severity of fiber atrophy in the case of diabetic amyotrophy predominated over the other cases. 4) The findings are suggesting that morphologic changes of muscle fibers are highly incident in diabetic patients even in case without any clinical sign of neuromuscular disorders. Although pathogenesis of them are not known, the disorder of neurtrophism might play more important role than muscle fiber changes due to diabetic metabolic disorders and/or vascular changes.
近畿大学の論文
1977-12-25

<原著>糖尿病生検筋の光顕的および電顕的研究 : 特に"Diabetic amyotrophy"と通常の糖尿病例との比較を中心として

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