<原著>逆流性食道炎 : 内視鏡像ならびに病理組織学的変化を中心として

概要

論文の詳細を見る
It is generally held that reflux esophagitis has less congruity within its endoscopic finding, histological abnormality and symptoms. This opinion has been investigated laying stress on erosive or ulcerlative changes, but reflux esophagitis occurs from the contact with the esophagus by the duodenal contents or gastiric juice. Therefore, a more detailed investigation on the change of mucosal epithelium was done. An esophagoscopy was performed on 85 patients with reflux esophagitis symptoms. Biopsy specimens which included full mucosal thickness were taken in 52 patients, and their histological changes were investigated. Moreover, studies were experimentally performed to cause esophagitis in mongrel dogs to investigate their endoscopic findings and histological changes. As a result, besides erosions and ulcers, several epithelial changes were seen, such as vascularization of epithelium, elongated papillae, down growth of rete ridges, spongiosis, basal cell hyperplasia and etc. These changes can be considered as the results of reflux esophagitis. When comparing alkaline esophagitis with acid peptic esophagitis, the former is diffuse but the latter is comparatively local and tends to form ulcers.
近畿大学の論文
1977-09-25