<原報>発白血病性化合物 N-ニトロソ-N-ブチル尿素誘導体の研究 : 第 1 報 N- ニトロソ-N, N′-ジブチル尿素および N- ニトロソ-N-ブチル-N′, N′- ジメチル尿素の合成

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In relation to our studies on N-nitroso-N-butylurea (NBU), noted for its high leukemogenic potency, the synthesis of its derivatives has been made in order to investigate their carcinogenic activities. In this report, the two head-titled compounds, N′-butyl-NBU (B-NBU) and N′, N′-dimethyl-NBU (DM-NBU) were synthesized by the reaction of butylisocianate with butylamine or dimethylamine respectively, followed by nitrosoation by an usual method. For the both substances, detection was made by thin-layer-chromatography, purification by column-chromatography and also identification by UV, IR and NMR spectra and elemental analysis. IR and NMR spectra of B-NBU and nitrosoation of N, N′-dibutylurea were discussed a little.
共立薬科大学の論文
1974-02-25