Neurons Expressing Phosphodiesterase 10A mRNA in Rat Brain : In situ Hybridization

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The mRNA expression of phosphodiesterase (PDE) 10A, a cGMP-binding cAMP PDE and cAMP-inhibited cGMP PDE, was examined in rat brain by in situ hybridization. The Northern blot analysis demonstrated expression of a single species of about 9,100-base long mRNA in various parts of rat brain. The most abundant expression of PDE10A mRNA was detected in the caudate-putamen, or striatum. In situ hybridization demonstrated that neurons in rat brain expressed PDE10A mRNA. Morphology of PDE10A neurons was different from one brain region to another ; mostly from medium-sized to small granule cells. The morphologically same types of neurons were not always positive even in single nuclei or regions. A number of PDE10A neurons were located in the layer VI of the cerebral cortex and the caudateputamen. Many or a moderate number of PDE10A neurons were observed in the external plexiform layer and the internal granule cell layer of the olfactory bulb, anterior olfactory nucleus, olfactory tubercle, piriform cortex, layer II and III of the cerebral cortex, dentate gyrus and fields CA 1 to CA3 of the hippocampus, amygdaloid nuclear complex, the granule cell layer of the cerebellum and the deep cerebellar nuclei. Solitary or scattered PDE10A neurons were found throughout the brain. The distinctive distribution of PDE10A neurons in rat brain suggests that this degradation enzyme plays indispensable role (s) in functions proper to given neuronal populations.
香川県立保健医療大学の論文

Neurons Expressing Phosphodiesterase 10A mRNA in Rat Brain : In situ Hybridization

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