<SESSION>HOW FAR INTENSITIVE INSTILLATION WILL GET RID OF TRITIUM FROM BODY OF RATS?
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概要
- 論文の詳細を見る
Following a single administration of tritiated water (HTO) by injection, rats daily received instillation of one of the following fluids, Ringer's solution, 10% glucose, low molecular dextrane of KN2B fluid maintenance, through into a tail vein. In some experiments, a diuretic, sodium acetazolamide, was also administerd by daily intramuscular injection in combination with instillation. After 8 days treatment, rats were sacrificed and total and tissue bound tritium activities in various tissues and blood were determined. All fluids tested were found to enhance successfully the excretion of the incorporated tritium. Especially, joint administration of Ringer's solution and sodium acetazolamide facillitated the decrease of tritium activity in urine most effectively. The biological half-life in joint administrated rats was shortend to 1.2 days in contrast to 3.0 days in control rats and total tritium activity of various tissues decreased to about one tenth that of tissues in control rats. These enhancing effects of instillation treatments were observed in prolonged treatment up to 75 days.
- 核融合科学研究所の論文
著者
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ICHIMASA YUSUKE
Department of Environmental Sciences, Faculty of Science, Ibaraki University
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AKITA YASUKAZU
Department of Biology, Faculty of Science, Ibaraki University
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Kitamura Masami
Department of Cardiology, Mie Central Medical Center
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Ichimasa Yusuke
Department Of Biology Faculty Of Science Ibaraki University
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Abe Miyuki
Department Of Neurosurgery Iwate Medical University
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Akita Y
Department Of Biology Faculty Of Science Ibaraki University
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Akita Yasukazu
Department Of Biology Faculty Of Science Ibaraki University
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Kitamura Masami
Department Of Biology Faculty Of Science Ibaraki University
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Chikuuti Masaaki
Department of Biology, Faculty of Science, Ibaraki University
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Chikuuti Masaaki
Department Of Biology Faculty Of Science Ibaraki University
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Iwata Yoshiyuki
Res. Center For Charged Particle Therapy National Inst. Of Radiological Sciences
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Fukusima Yuuko
Department of Biology, Faculty of Science, Ibaraki University
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Fukusima Yuuko
Department Of Biology Faculty Of Science Ibaraki University
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- HOW FAR INTENSITIVE INSTILLATION WILL GET RID OF TRITIUM FROM BODY OF RATS?