Two types of lymphatic invasion in lymph node metastasis with special references to the morphology of gastric carcinomas and immunohistology of E-cadherin and beta-catenin

スポンサーリンク

概要

• 論文の詳細を見る

• Two types of lymphatic invasion were distinguishable in lymph nodes (LN) withmetastasis of a gastric carcinoma (GC). One was an embolic (E) type of lymphaticinvasion that was characterized with embolus of carcinoma cells in collectinglymphatics. Infiltration of carcinomas as single cells or as tiny clusters throughlymphatic capillaries were features of the other infiltrative (I) type of lymphaticinvasion and were found in the interstitial spaces of peri-lymphnodal fat tissues. Thelatter was an early event during metastasis, even when not yet apparent in LN. Bothtypes of lymphatic invasion coexisted, not infrequently, in advanced stages, but pure Itype occurred exclusively in diffuse type GC ( χ2< 0.005), regardless of the existence ofmetastasis in LN. E type was more frequently encountered solely or predominantly inintestinal type GC ( χ2< 0.05). Of the destructive lesions of collecting lymphatics, fibrousocclusion or stenosis and large emboli were seen in intestinal type GC ( χ2< 0.005).Early I type lesions were more seen in diffuse type GC ( χ2< 0.005). The incidence ofdestruction of collecting lymphatics by carcinoma cells from outside and the existenceof single cells in collecting lymphatics were seen more in diffuse type GC, but notsignificantly. Immunohistology revealed that E-cadherin (Ec) and β-catenin(βc) wereexpressed positively in cytoplasm of carcinoma cells of diffuse GC at 50.0% and 78.5%,respectively. However, βc of carcinoma cells exhibiting I type of lymphatic invasionwere expressed negatively or much less. The mechanism of I type of lymphatic invasion,its low expression of βc, and the heterogeneity of GC were discussed. It is necessary toclarify the I type of lymphatic invasion to gain improvements in curability.

• 神戸大学の論文

著者

• Sakamoto Haruhiko

  Department Of Pathology And Host Defense Faculty Of Medicine Kagawa University

• Sakamoto H

  Department Of Pathology Kagawa Medical University

• Kuwabara H

  Second Division Department Of Pathology Osaka Medical College

• Kuwabara Hiroko

  Second Department Of Pathology Kagawa Medical University

• Uda Hirotsugu

  Department Of Pathology Saiseikai Tondabayasi Hospital

• Obana Shunsaku

  Department of Pathology, Kagawa Medical University

• Obana Shunsaku

  Department Of Pathology Kagawa Medical University

• SAKAMOTO HARUHIKO

  Department of Oral Surgery, Dokkyo University School of Medicine

関連論文

• Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
• Hypoxia-inducible factor-2α is involved in enhanced apoptosis in the placenta from pregnancies with fetal growth restriction
• CARDIOVASCULAR EFFECTS OF ISOPROTERENOL AND POSSIBLE ANTAGONISTIC ACTIONS OF PROPRANOLOL AND PERHEXILINE
• Immunohistochemical adrenomedullin expression is decreased in the placenta from pregnancies with pre-eclampsia
• Adult T Cell Leukemia Presenting as Multiple Submucosal Tumors of the Intestine: Detection of HTLV-I DNA by Polymerase Chain Reaction
• Medulloblastoma with myogenic differentiation showing double immunopositivity for synaptophysin and myoglobin
• Antibody Mediated Ligation of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) on Neutrophils Enhances Adhesion to Cultured Human Dermal Microvascular Endothelial Cells
• Small cell carcinoma of the gall-bladder with intestinal metaplastic epithelium
• Two types of lymphatic invasion in lymph node metastasis with special references to the morphology of gastric carcinomas and immunohistology of E-cadherin and beta-catenin
• The study of catecholamine, acetylcholine and bradykinin in buccal circulation in dogs.

スポンサーリンク