Antibody Mediated Ligation of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) on Neutrophils Enhances Adhesion to Cultured Human Dermal Microvascular Endothelial Cells

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概要

• 論文の詳細を見る

• We investigated the effects on leukocyte adhesion to cultured human dermal microvascular endothelial (DMvE) cell by antibody mediated ligation of platelet/endothelial cell adhesion molecule-1 (PECAM-1) on neutrophils. Preincubation of neutrophils with anti-PECAM-1 antibody markedly enhanced their adhesion to DMvE cells, while the adhesion-increasing action was cancelled out by anti-CR3 or anti-LFA-1 beta (CD18) antibody. These findings suggest that ligation of PECAM-1 on neutrophils increases their adhesion to cultured DMvE cells depending on the beta 2 integrin family, and PECAM-1 may have a crucial role in dermal inflammation.

• 神戸大学の論文

著者

• Sakamoto Haruhiko

  Second Department Of Pathology Kagawa Medical School

• Sakamoto H

  Department Of Pathology Kagawa Medical University

• Tanaka Sumiko

  Second Division Department Of Pathology Kagawa Medical University

• Kuwabara H

  Second Division Department Of Pathology Osaka Medical College

• Kuwabara Hiroko

  Second Department Of Pathology Kagawa Medical University

• Uda Hirotsugu

  Department Of Pathology Saiseikai Tondabayasi Hospital

• Uda Hirotsugu

  Second Department Of Pathology Faculty Of Medicine Osaka University

• Oryu M

  Kagawa Medical School Kagawa Jpn

• Oryu Makoto

  Second Department Of Pathology Kagawa Medical School

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