Cell-type-specific Augmentation of the Tumoricidal Activity of Polymeric Adriamycin Combined with Galactosamine

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概要

• 論文の詳細を見る

• The optimization of drug delivery system with approaches to a target in structure has been implicated to play a role in cancer chemotherapy, because it can reduce the adverse effects. However, this system partly reduces the direct cytotoxicity of anticancer drugs against tumor cells, in comparison to its free form. In the present study, poly(ﾎｱ- malic acid) adriamycin (poly ADR) coated with saccharides including galactosamine which recognizes galactose-lectin specific to hepatocytes was prepared, and its cytotoxicities against Hep G2 cells (human hepatoblastoma), AZ521 cells (human gastric cancer) and KNS cells (human lung cancer) was evaluated using an in vitro cytotoxicity assay. In both AZ521 cells and KNS cells, poly ADR as well as poly ADR coated with glucosamine, glactosamine or mannosamine provided relatively lower cytotoxicities than the free form of ADR. In contrast, Hep G2 cells were to more efficiently sensitized, compared with the free form of ADR or poly ADR combined with or without glucosamine or mannosamine (P<0.01, respectively). These results indicate that poly ADR coated with galactosamine used as a cell recognition element is thus applicable for targeting cancer chemotherapy in the treatment of hepatocellular carcinoma.

• 長崎大学の論文

著者

• 中田 恵輔

  長崎大学保健管理センター

• 中田 恵輔

  長崎大学第一内科

• Keisuke Nakata

  Health Research Center Nagasaki University

• NAKATA Keisuke

  The First Department of Internal Medicine, Nagasaki University School of Medicine

• NAKATA KEISUKE

  Health Research Center, Nagasaki University School of Medicine

• ISHII Nobuko

  Health Research Center, Nagasaki University

• Nobuko Ishii

  Health Research Center Nagasaki University

• Katsuro ICHINOSE

  Second Department of Surgery, Nagasaki School of Medicine

• Ichinose Katsuro

  Second Department Of Surgery Nagasaki University School Of Medicine

• Katsuro Ichinose

  Second Department Of Surgery Nagasaki School Of Medicine

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