EFFECT OF CHOLECYSTECTOMY ON DUODENOGASTRIC REFLUX, GASTRIC MUCOSA AND SERUM GASTRIN LEVEL

概要

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Cholecystectomy is associated with an increase in the incidence of gastritis and may contribute to the post-cholecystectomy syndrome. In this prospective study we evaluated the relationship of duodenogastric reflux (DGR) with gastric mucosal changes, serum gastrin level, the presence of Helicobacter pylori (HP) and dyspeptic symptoms in cholecystectomized patients. Gastritis rate was 31 times more in DGR (+) when compared with DGR (-) patients, and 24 times more in patients with dyspeptic symptoms than without dyspepsia. HP was positive in 23% of patients with DGR, and it was 11% of patients without DGR. There was no difference between serum gastrin levels of the groups according to DGR, gastritis and dyspeptic symptoms (p>0.05). Therefore, this prospective study suggests that excessive DGR may be responsible for persistence of symptoms after cholecystectomy by causing gastric mucosal damage.
名古屋市立大学の論文
2000-07-01