<WORKSHOP : Skin Wrinkling : Mechanisms, Protection and Therapy>AGING REPRESENTS A CONTINUOUS REARRANGEMENT OF COLLAGEN AND ELASTIC FIBERS THAT BEGINS AT BIRTH

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We have demonstrated that a major feature of the "aging" of connective tissue is continuous alteration of the three-dimensional construction of the fibrous components that begins at birth. The postnatal growth involves the dynamic rearrangement of both collagen and elastic fibers. The rearrangement is subsequently fitted during adulthood, producing severe deformation of the elastic fibers. At the same time, there is evidence of an incomplete rebuilding of elastic fibers in relation to the deformative change. However, these fibers are deposited around the collagen bundles, resulting in an interlocking form. These features provide an explanation for the manifestations of "aged" skin, such as sagging and wrinkling. The tortuously fixed elastic fibers imply a loss of both their original elasticity and the ability to restore their shorter and straighter forms, resulting also in a loss of the tightly fit property of the skin. Interlocking of both collagen and elastic fibers should disturb instantaneous slipping of the two independent fibers, and thus decrease tissue compliance to produce wrinkling of the skin.
名古屋市立大学の論文
2000-01-31