<Original Paper>Influence of Acyclovir on Antibody Production of Antibody to Chickenpox

概要

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Titers of immunoglobulin (Ig) G and 1gM antibody to varicella zoster virus (VZV) were measured in 20 pediatric patients with chickenpox during treatment with acyclovir, an antiviral agent. Acyclovir doses, each 80 mg/kg/day, were administered for 5 days, beginning within 4 days after the onset of the rash. All patients displayed positive IgG and/or 1gM anti-VZV antibodies. No significant difference was noted in the IgG (p = 0.417) or IgM titer (p = 0.846) between patients treated within 24 hours of the onset of the rash and those treated one or more days after onset. No significant differences was noted in the IgG (p = 0.2 12) or IgM titer (p = 0.570) between patients tested within 10 days after the onset of the rash and those tested more than 10 days after. We conclude that administration of acyclovir does not affect anti-VZV antibody production in patients with chicken-pox.
獨協医科大学の論文
2003-03-25