<Originals>Early postnatal development and learning ability of the rat offspring prenatally exposed to methylazoxymethanol acetate
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概要
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Methylazoxymethanol acetate (MAM) was injected intraperitoneally into female Crj : CD rats on day 13 of pregnancy at a dose of 30mg/kg. The reflex development, motor coordination, and motor capacity of their offspring were assessed from the early postnatal period until weaning. In addition, the learning behavior was investigated after weaning. Rats exposed to MAM in utero showed a significant delay in the cliff avoidance reflex and negative geotaxis. With respect to motor coordination and motor capacity, rats exposed to MAM showed significant delays in achieving control of the direction and angle of the body in swimming, as well as in the use of all four limbs. In post-weaning learning behavior, the time required to complete a T-maze was significantly prolonged and the number of errors significantly increased in the MAM offspring. Pre-weaning disorders detected in the neurological maturation of rats exposed to MAM in utero provide information which could be of value in predicting behavioral impairments in mature animals.
- 近畿大学の論文
著者
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Tanimura Takashi
Kinki University
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Tanimura T
Kinki University
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Tanimura Takashi
First Department Of Anatomy Kinki University School Of Medicine
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YAMAMOTO Yoshitame
First Department of Anatomy, Kinki University School of Medicine
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Yamamoto Y
Kinki Univ. School Of Medicine Osaka Jpn
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Yamamoto Yoshitame
First Department Of Anatomy Kinki University School Of Medicine
関連論文
- Comments from the Behavioral Teratology Committee of the Japanese Teratology Society on OECD Guideline for the Testing of Chemicals, Proposal for a New Guideline 426, Developmental Neurotoxicity Study, Draft Document (September 2003)
- Evaluation of a core battery of tests for detecting behavioral dysfunction of rat offspring induced by retinoic acid : Collaborative work II of the Japanese behavioral teratology committee
- EFFECTS OF THE NEONATAL VITAMIN A EXPOSURE ON BEHAVIORS OF ADULT RATS
- Comments from the Developmental Neurotoxicology Committee of the Japanese Teratology Society on the OECD Guideline for the Testing of Chemicals, Proposal for a New Guideline 426, Developmental Neurotoxicity Study, Draft Document (October 2006 version), an
- Comments from the Behavioral Teratology Committee of the Japanese Teratology Society on OECD Guideline for the Testing of Chemicals, Proposal for a New Guideline 426, Developmental Neurotoxicity Study, Draft Document (September 2003)
- EFFECTS OF FOOD RED NO. 102 (NEW COCCINE) ADMINISTERED ORALLY TO PREGNANT MICE ON THE PRE-AND POSTNATAL DEVELOPMENT OF THEIR OFFSPRING (The Fourth Meeting for the Study of Toxic Effect)
- Alternatives to animal experiments in developmental toxicity studies
- Early postnatal development and learning ability of the rat offspring prenatally exposed to methylazoxymethanol acetate
- P-54 The Effects of Prental Retinal Exposure on Behaviors and Functions of Rat offspring.(Proceedings of the 27th Annual Meeting)
- Behavioral and morphological alterations in rats prenatally treated with methylazoxymethanol acetate (MAM)
- Memories of the first five years of the Japanese Teratology Society
- In Memoriam Dr.Hideo Nishimura(1992-1995)〔含 肖像〕
- Multilateral approaches to toxicity evaluation
- Brain damage associated with prenatal environmental factors (Proceedings of the 6th International Symposium on Developmental Disabilities,held in Tokyo,Japan, november 18-19,1993