<Originals>Effects of cadmium on the tension of isolated blood vessels from stroke-prone SHR and WKY

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概要

• 論文の詳細を見る

• It is known that the oral or the parenteral administration of cadmium salts (Cd^<2+>) produces the hypertension in animals and humans. Many investigations have been carried out to clarify the mechanism of Cd^<2+>-induced hypertension by using the isolated blood vessels. But there is no report that argued about the relationship of Cd^<2+> to hypertension. In this experiment, the author studied the effects of Cd^<2+> on the tonus and on the responses to the vasocontractile agents by using the isolated blood vessels from stroke-prone SHR (SHRSP) and Wistar Kyoto Rat (WKY), and discussed the hypertensive mechanism of Cd^<2+> from the results obtained. Cd^<2+> produced contraction in a dose-dependent manner in the aortas and superior mesenteric arteries from SHRSP and WKY. The contraction by Cd^<2+> was much larger in the aorta than in the superior mesenteric artery, also being larger in SHRSP than in WKY in the both vessels. Besides the contraction by Cd^<2+> was Ca^<2+>-dependent, and was not affected by the alpha sympathetic blocking agent, phentolamine. The dose-response (D-R) curves for K^+, serotonin and noradrenaline were shifted upward without shifting to the right or to the left by the low concentrations of Cd^<2+> and these were shifted downward by the high concentrations of Cd^<2+> in the aortas from SHRSP and WKY. As to the potentiating effect of Cd^<2+> there was no significant difference between SHRSP and WKY. The D-R curve for Ba^<2+> was shifted downward by the low and high concentrations of Cd^<2+> in SHRSP and WKY. The D-R curves for K^+, Ba^<2+> and noradrenaline were shifted downward in the low and high concentrations of Cd^<2+> in the superior mesenteric arteries from SHRSP and WKY. The D-R curve for serotonin was shifted upward by the low concentration of Cd^<2+> in SHRSP and WKY, but that was shifted downward by the high concentration of Cd^<2+> in SHRSP and WKY. As for the potentiating effect of Cd^<2+> on the serotonin-induced contractions there was no significant difference between SHRSP and WKY. The relaxation of strip by the washing after the contraction was not prolongated by the treatment of Cd^<2+> in the aortas and the mesenteric arteries from SHRSP and WKY. These results suggest that Cd^<2+>-induced hypertension might be produced by the contraction of blood vessels and by the potentiating effect on the responses to the vasocontractile agents, being larger in SHRSP than in WKY.

• 近畿大学の論文

著者

• YAMANISHI Hiromichi

  Department of Pharmacology Kinki University School of Medicine

• Yamanishi H

  Department Of Pharmacology Kinki University School Of Medicine

関連論文

• Effects of Local Anesthetics on the Responses to Some Contractile Agents, Especially in Relation to Ca
• Effects of cadmium on the tension of isolated blood vessels from stroke-prone SHR and WKY
• Abnormal responses to the vasoconstrictor sgents in isolated aortas from SHRSP, especially in relation to aging
• Spare Receptors in Aortas from Stroke-Prone SHR and WKY
• Effect of Ca2+ Contents in Medium on the Responses to Some Contractile Agents in Isolated Portal Veins from SHRSP and WKY
• Effect of cadmium ions on the tension of isolated vascular smooth muscles from SHRSP

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