Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease : Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer's Disease
スポンサーリンク
概要
- 論文の詳細を見る
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, accompanied by neuronal loss and the formation of senile plaques in the brain. Glial cells, such as microglia, have been shown to be activated and induce chronic inflammatory responses in AD brain. The endoplasmic reticulum (ER) functions to facilitate protein folding. However, ER stress occurs when cells are exposed to stress. Mounting evidence suggests that ER stress is involved in the pathology of AD. Meanwhile, recent findings suggested crosstalk between ER stress and immune function. However, the mechanisms linking the progression of AD with ER and immunological stress are still not clear. In the present paper, we review and discuss recent results regarding the mechanism of AD pathogenesis, focusing on ER stress and immunological stress.
- 2012-03-20
著者
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Ozawa Koichiro
Department Of Pharmacotherapy Division Of Clinical Pharmacotherapeutics Programs For Applied Biomedi
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HOSOI Toru
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Hosoi Toru
Department Of Pharmacotherapy Graduate School Of Biomedical Sciences Hiroshima University
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Ozawa Koichiro
Department Of Pharmacotherapy Graduate School Of Biomedical Sciences Hiroshima University
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