Bacitracin Upregulates mbrAB Transcription via mbrCD to Confer Bacitracin Resistance in Streptococcus mutans
スポンサーリンク
概要
- 論文の詳細を見る
Streptococcus mutans is a bacterial cause of dental caries that is resistant to bacitracin. The aim of this study was to elucidate the mbrABCD-related bacitracin resistance mechanism of S. mutans. Transcriptome data demonstrated that the expression levels of 33 genes were induced more than twofold by bacitracin. Fourteen genes were selected from the upregulated genes, and defective mutants of these genes were constructed for measurement of their sensitivity to bacitracin. Among the mutants, only the mbrA- or mbrB-deficient mutants exhibited 100- to 121-fold greater sensitivity to bacitracin when compared with the wild-type strain. Moreover, knockout of the mbrC and mbrD genes abolished the bacitracin-induced mbrAB upregulation. These results suggest that both mbrC and mbrD are required for mbrAB upregulation that confers the bacitracin-resistant phenotype on S. mutans.
- 2011-11-20
著者
-
Takahashi Tomihisa
Department of Anatomy, Nihon University School of Dentistry
-
Suzuki Naoto
Division Of Functional Morphology Dental Research Center Nihon University School Of Dentistry:depart
-
Mikami Yoshikazu
Department Of Anatomy Nihon University School Of Dentistry
-
Tsuda Hiromasa
Division Of Functional Morphology Dental Research Center Nihon University School Of Dentistry
-
Takahashi Tomihisa
Department Of Anatomy Nihon University School Of Dentistry
-
OTSUKA Kichibee
Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry
-
Suzuki Naoto
Division Of Functional Morphology Dental Research Center Nihon University School Of Dentistry
-
Otsuka Kichibee
Division Of Functional Morphology Dental Research Center Nihon University School Of Dentistry
関連論文
- Autoregulatory mechanism of Runx2 through the expression of transcription factors and bone matrix proteins in multipotential mesenchymal cell line, ROB-C26
- -544- EFFECTS OF LIPOLYSIS ON ESTERIFICATION AND TRANSFER OF CHOLESTEROL
- SELECTIVITY IN REMOVAL OF LOW DENSITY LIPOPROTEIN (LDL) BY PLASMAPHERESIS (PP) AND NORMALIZATION OF PLASMA LDL BY COMBINATION THERAPY WITH PP AND DRUGS IN FAMILIAL HYPERCHOLESTEROLEMIA : Atherosclerosis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING
- Inhibitory Effects of a Tryptamine Derivative on Ultraviolet Radiation–Induced Apoptosis in MC3T3-E1 Mouse Osteoblasts
- Early Expression of Human J Chain and μChain Gene in the Fetal Liver
- SSH-BM-I, a Tryptamine Derivative, Stimulates Mineralization in Terminal Osteoblast Differentiation but Inhibits Osteogenesis of Pre-committed Progenitor Cells
- ASSESSMENT OF EFFICACY OF LDL-APHERESIS BY RECOVERY PROCESS OF PLASMA LIPOPROTEINS IN A PATIENT WITH HOMOZYGOUS FAMILAIL HYPERCHOLESTEROLEMIA
- RANKL induces the expression of carbonic anhydrase II, cathepsin K, and matrix metalloproteinase-9 in RAW264.7 cells(15thAnnual Meeting of the Society for Hard Tissue Regenerative Biology,Session 2)
- IL-1α Stimulates the Formation of Osteoclast-like Cells via RANK-RANKL Signaling System by Osteoblasts and Monocytes(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- A Tryptamine Derivative, SST-VEDI-1, Inhibits Apoptosis and Stimulates Mineralization in Osteoblasts
- A New Synthetic Compound, SST-VEDI-1, Inhibits Osteoblast Differentiation with a Down-Regulation of the Osterix Expression
- -1357- CORONARY RISK FACTERS FOR SILENT MYOCARDIAL ISCHEMIA IN DIABETIC PATIENTS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- FREQUENCY OF CORONARY VASOSPASUM ASSESSED BY PROVOCATION TESTS IN SILENT MYOCARDIAL ISCHEMIA OF DIABETIC PATIENTS
- Isolated Oculomotor Nerve Palsy in Churg-Strauss Syndrome
- Abducens Nerve Palsy and Horner Syndrome Due to Metastatic Tumor in the Cavernous Sinus
- Inhibitory Effects of a Tryptamine Derivative on Ultraviolet Radiation-Induced Apoptosis in MC3T3-E1 Mouse Osteoblasts
- SSH-BM-I, a Tryptamine Derivative, Stimulates Mineralization in Terminal Osteoblast Differentiation but Inhibits Osteogenesis of Pre-committed Progenitor Cells
- Bacitracin Upregulates mbrAB Transcription via mbrCD to Confer Bacitracin Resistance in Streptococcus mutans
- Abducens Nerve Palsy and Postganglionic Horner Syndrome with or without Severe Headache
- Assessment of Efficacy of LDL-apheresis by Recovery Process of Plasma Lipoproteins in a Patient with Homozygous Familial Hypercholesterolemia(LDL-Apheresis)