Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2
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概要
- 論文の詳細を見る
he basic helix–loop–helix protein E2-2 is known to play a role in quiescence of endothelial cells (ECs). However, it is unclear how the activity of E2-2 is controlled in the cells. In this study, we identified FAM96B as an interaction partner of E2-2. FAM96B interfered with E2-2-mediated effects on luciferase reporter activities. Furthermore, the suppression of vascular endothelial growth factor receptor 2 promoter activity by E2-2 was rescued by the expression of FAM96B in a dose-dependent manner. Interestingly, FAM96B decreased the expression of ectopic and endogenous E2-2 proteins. Mutational analysis revealed that the middle region of FAM96B is required for the limited expression of E2-2 protein. When FAM96B was expressed in ECs, the EC migration, proliferation, and tube formation were potentiated. Taken together, these findings suggest that FAM96B acts as a regulator of E2-2 through the control of its protein expression.
- 2011-10-10
著者
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Itoh Fumiko
Department Of Experimental Pathology Graduate School Of Comprehensive Human Sciences University Of T
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Tanaka Aya
Department Of Experimental Pathology Graduate School Of Comprehensive Human Sciences University Of T
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Tanaka Aya
Department Of Applied Chemistry Graduate School Of Engineering Hiroshima University
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Itoh Susumu
Department Of Experimental Pathology Graduate School Of Comprehensive Human Sciences University Of T
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Kato Mitsuyasu
Department Of Experimental Pathology Graduate School Of Comprehensive Human Sciences University Of T
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Kato Mitsuyasu
Department Of Biochemistry Cancer Institute Of The Japanese Foundation For Cancer Research (jfcr)
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Itoh Susumu
Department Of Electrical Engineering Faculty Of Science And Technology Science University Of Tokyo
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Nakano Naoko
Department Of Experimental Pathology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Ohya Hirotoshi
Department Of Experimental Pathology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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YANG Weiwen
Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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KISHIMOTO Fukiko
Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Yang Weiwen
Department Of Experimental Pathology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Kishimoto Fukiko
Department Of Experimental Pathology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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