A Clinical Study of the Prognostic Factors for Postoperative Early Recurrence in Patients who Underwent Complete Resection for Pulmonary Adenocarcinoma

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概要

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• Purpose: The 2-[F-18]-Fluoro-2-deoxy-D-glucose (FDG) uptake in positron emission tomography (PET) and serum neutrophil/lymphocyte ratio (NLR) are recently noteworthy prognostic factors. We studied the prognostic factor to predict early recurrence after curative resection for pulmonary adenocarcinoma including FDG uptake and NLR.Methods: We performed a retrospective review of 23 patients who underwent a complete resection for pulmonary adenocarcinoma. The patients were divided into 2 groups: 19 patients in the disease-free group, and 4 patients in the recurrent group. Clinical and pathological factors concerning the recurrence within 1 year of surgery were analyzed between two groups.Results: No significant differences between the recurrent group and disease-free group was seen in age, gender, CEA, NLR, CRP, pathological stage, pleural invasion, pathological grading, Ki-67 expression, venous invasion and lymphatic invasion. The SUVmax was significantly elevated in the recurrent group (12.5 ± 2.01 vs. 5.70 ± 3.97, p = 0.0094). Tumor size was significantly larger in the recurrent group (5.58 ± 0.71 vs. 3.62 ± 1.33 cm, p = 0.0058). The first, recurrent sites in 4 patients were brain, in 3 patients; and lung, in 1 patient.Conclusion: Both tumor size and SUVmax are possible predictors of early recurrence after curative resection in patients with pulmonary adenocarcinoma. Although it is impossible to determine the SUVmax as an independent prognostic factor, the SUVmax may be one of the predictors of early hematogenous recurrence in surgically treated pulmonary adenocarcinoma.

• 2011-12-01

著者

• Kimura Daisuke

  Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine

• Fukuda Ikuo

  Department Of Cardiovascular Surgery Hirosaki University School Of Medicine

• Hatanaka Ryo

  The First Department Of Surgery Hirosaki University School Of Medicine

• Kimura Daisuke

  Department Of Informatics The Graduate University For Advanced Studies National Institute Of Informa

• Tsushima Takao

  Department Of Thoracic And Cardiovascular Surgery Hirosaki University Graduate School Of Medicine

• Sakai Takehiro

  Department Of Surgery Aomori Rosai Hospital

• Yamada Yoshitsugu

  The Department Of Surgery 1 Hirosaki University School Of Medicine

• Yamada Yoshitsugu

  Department Of Anesthesiology And Critical Care Medicine Yokohama City University Graduate School Of

• Tsushima Takao

  The Department Of Surgery 1 Hirosaki University School Of Medicine

• Hatanaka Ryo

  Department Of Surgery Hirosaki Chuo Hospital

• Yamada Yoshitsugu

  Department Of Anesthesia And Pain Relief Center The University Of Tokyo Hospital

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