Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases
スポンサーリンク
概要
- 論文の詳細を見る
Chronic inflammation appears to underlie most, if not all, the chronic diseases of today, including cardiovascular disease, type 2 diabetes, chronic kidney disease, Alzheimer's disease and cancer. We have demonstrated that obesity induces chronic local inflammation in adipose tissue. We also found that chronic inflammation is crucially involved in the development of heart failure and chronic kidney disease. In this article, I review recent findings reported by my group and others regarding the mechanisms underlying the chronic inflammatory processes commonly observed in adipose tissue, heart and kidney. I then discuss the key features of the chronic inflammation seen in chronic diseases. (<i>Circ J</i> 2011; <b>75:</b> 2739-2748)<br>
- 2011-11-25
著者
-
Manabe Ichiro
Department Of Caldiology University Of Tokyo
-
Manabe Ichiro
Department Of Cardiovascular Medicine And Global Coe Graduate School Of Medicine The University Of T
関連論文
- OJ-217 Genetic Variations of Mrf-2/Arid5B Confers Risk of Coronary Atherosclerosis in the Japanese Population(Genetics/Genetically engineered models/Gene therapy-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Adipose Tissue Remodeling and Malfunctioning in Obesity Revealed by in vivo Molecular Imaging
- PJ-482 The Polymorphism in the Adiponectin Gene is Associated with Susceptibility to Coronary Artery Disease(Atherosclerosis, clinical-11 (H) PJ81,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society
- Angiotensin II stimulation induces TGF β and its related proteins in cardiac fibroblasts
- Genetic Variations of Mrf-2/Arid5b Confer Risk of Coronary Atherosclerosis in the Japanese Population
- PE-566 Variations in the Origins of Mature Smooth Muscle Cells with SM1/2 Expression in Vascular Remodeling(Development and differentiation-3 (M) PE97,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soci
- PE-320 Synthetic Retinoid (Am80) Suppresses Smooth Muscle Phenotypic Modulation and Neointima Formaion by Disrupting a Transcriptional Complex of KLF5/RAR/RXR(Vascular smooth muscles-2 (H) PE54,Poster Session (English),The 70th Anniversary Annual Scientif
- FRS-060 SUMOylation of KLF5 is a key molecular switch of transcriptional regulatory programs of lipid metabolism(New Insights into Metabolic Syndrome(02)(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-537 Identification of the Novel MEF2-Kruppel-like Factor 5 (KLF5) Network That Associates with Cardiovascular Disease(Molecular biology, vascular-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-411 KLF5 Controls Metabolic Stress Response in Metabolic Syndrome and Cardiovascular Disease(Diabetes/Obesity/Metabolic syndrome-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-174 Molecular Mechanism of Soluble Form of VEGFR-1 (sVEGFR-1)Expression in Vascular Endothelial Cell(Molecular biology, vascular(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-044 Long Pentraxin 3 (PTX3) is More Specific than C-reactive Protein (CRP) as a Marker for Vascular Inflammation(Atherosclerosis, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- The Significant Association of Genetic Polymorphisms in the KLF5 Gene with Coronary Artery Disease(Atherosclerosis, Clinical 9 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-168 Kruppel-like zinc-finger trascription factor 5 (KLF5) madiate immune responses in cardiovascular remodeling(Infection/Inflammation/Immunity 1 (H) : OJ20)(Oral Presentation (Japanese))
- Kruppel-Like Zinc-Finger Transcription Factor KLF5/BTEB2 ls a Target for Angiotensin II Signaling and an Essential Regulator of Cardiovascular Remodeling.
- Obese adipose tissue remodeling, malfunctioning, and chronic inflammation visualized by in vivo molecular imaging
- PJ-178 Free Fatty Acid, Palmitate, Induces Metabolic and Vascular Lipotoxicity via the IRE1 Arm of ER Stress Response Pathways(PJ030,Metabolic Syndrome 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 4 Bone marrow-derived cells contribute to vascular wall inflammation without differentiating into smooth muscle cells(Young Investigator's Award Finalists Lectures (YIA),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-343 Novel Regulatory Pathway of PDGF-A Chain as Mediated by Transcription Factor KLF5 through Cooperative Activation with NF-κB and Phorbol Ester(Molecular Biology, Vascular 3 (H) : PE59)(Poster Session (English))
- Proteomic Identification of a Transcriptional Represser of the Transcription Factor KLF5/BTEB2
- KLF5 not only Synergistically Activates PDGF-A Gene with NFκ B but also Accelerates SMC Proliferation
- Angiotensin II downregulates renal expression of anti-aging gene, kiotho, and exogenous klotho gene transfer ameliorates angiotensin II-induced renal damage
- DPE-071 Retinoic Acid Receptor Antagonist Ameliorates Pressure Overload-Induced Cardiac Hypertrophy and Remodeling(DPE12,Cardiomyopathy/Hypertrophy (Basic) (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation
- OE-057 Saturated Fatty Acid, Palmitate, Promotes Smooth Muscle Phenotypic Modulation and Exacerbates Neointima Formation(OE10,Atherosclerosis, Basic 1 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- FRS-104 KLF5 Controls Tissue Remodeling in Cardiovascular and Kidney Diseases via S100 Proteins(FRS21,New Insights into Chronic Kidney Disease and Renal Circulation (H),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese
- FRS-093 Significance of the Transcription Factor KLF5 in Myocardial Hypertrophy in Response to Pressure Overload(FRS19,Genetic Abnormalities in Cardiac Hypertrophy and Cardiomyopathy (M),Featured Research Session (English),The 73rd Annual Scientific Meeti
- FRS-079 Rad51 Plays a Pivotal Role in Adipose Tissue Obesity and Systemic Insulin Resistance(FRS16,Basic Mechanisms of Lipid Disorders and Metabolic Syndrome (H),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circul
- PJ-412 S100A8 and S100A9 are novel proinflammatory signal mediators in cardiovascular and metabolic disease(Atherosclerosis, basic(07)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-183 KLF5 Plays an Important Role in Endoplasmic Reticulum Stress Response in both Cardiovascular and Metabolic Systems(Diabetes/Obesity/Metabolic syndrome(05)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- PE-030 Endoplasmic Reticulum Stress Signaling Modulates Smooth Muscle Phenotypes(Atherosclerosis, basic(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-256 Significance of the Transcription Factor KLF5 in Myocardial Hypertrophy in Response to Pressure Overload(Cardiac hypertrophy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-235 Identification of Metabolic Syndrome Related-unknown Key Molecule With Using siRNA Library(Metabolism/Biochemistry/Energetics(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-093 KLF5 controls fibrosis in cardiovascular and kidney diseases via S100 protein expression(Renal Dysfunction and Cardiovascular Disease(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-539 S100A4 is induced by Angiotensin II in Fibrosis and the Target of Beraprost(Molecular biology, vascular-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-379 Nanoparticle-mediated Systemic Delivery of siRNA Targeting KLF5 Inhibit Tumor Angiogenesis and Growth in Vivo(Genetics/Genetically engineered models/Gene therapy-2 (M) PE64,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of
- PE-324 Adiponectin May Effect on Angiotensin II Stimulations(Vascular smooth muscles-2 (H) PE54,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- SOX9 Controls Myofibroblast Differentiation in Response to TGF-β in Tissue Remodeling(Myocardial Ischemia-reperfusion, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Systemic Delivery of Retinoic Acid Receptor α Specific Agonist Inhibits In-Stent Restenosis by Inducing Differentiation of Smooth Muscle Cells(Vascular Smooth Muscle 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Adiponection Inhibits the Transcriptional Circuitry Controlling Vascular Remodeling in Smooth Muscle Cells(Vascular Smooth Muscle 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Kruppel-like Transcription Factor KLF5 is a Key Regulator Governing Adipocyte Differentiation(Metabolic Syndrome (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Serum Response Factor (SRF) Cofactors in Smooth Muscle Differentiation
- OJ-205 Smad Interacting Protein 1 Controls Arterial Valve Development(OJ35,Valvular Heart Disease/Pericarditis/Cardiac Tumor 1 (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-131 A novel mouse model of thoracic aortic aneurysm (Tsuri-ito model) revealed the protective property of TNF α against the rupture of aneurysm(PE022,Atherosclerosis, Basic (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japane
- OJ-092 S100A8 is a Novel Proinflammatory Mediator in Metabolic Syndrome(OJ16,Metabolic Syndrome (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-202 Chronic Inflammation, Macrophage Recruitment and CD8+ T Cell Activation in Obese Adipose Tissue Visualized by in vivo Molecular Imaging(OE35,Metabolic Syndrome (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circu
- OE-013 Platelet Kinetics in Thrombus Formation, and Inflammatory Status Revealed by in Vivo Molecular Imaging(OE03,Thromboembolism/Antithrombotic Therapy/Thrombolysis (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Cir
- OJ-258 Lysophosphatidylcholine induces insulin resistance via G-protein coupled receptor 4(Diabetes / Obesity / Metabolic syndrome(03)(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-301 "Black-hole phenomenon" may contribute to positive vascular remodeling with stent malapposition after implantation of sirolimus-eluting stents in swine coronary arteries(Intravascular endoscopy/Intravascular ultrasound(01)(I),Oral Presentation(Engl
- OE-114 Kruppel-like Zinc-finger Transcription Factor KLF5/BTEB2 is an Essential Regulator of Cardiovascular Remodeling(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
- FRS-095 KLF5 inhibitor Am80 reduces atherosclerosis in apolipoprotein E-knockout mice.(Inflammation and Cardiovascular Disease (IHD) : FRS12)(Featured Research Session (English))
- FRS-022 Adipogenesis in Obesity Requires Interplay between Differentiating Adipocytes, Stromal Cells and Blood Vessels(Diabetes/Obesity (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-009 Delivery of Endothelial PAS Domain Protein1 Gene Promotes Angiogenesis through the Transactivation of Both VEGF and Its Receptor, Flt-1(Vasoactive Compound/Growth Factor/Cytokine 1 (H) : OE2)(Oral Presentation (English))
- Delivery of Endothelial PAS Domain Protein1 Gene Promotes Anglogenesis through the Transactivation of Both VEGF and Its Receptor, Flt-1
- OJ-046 KLF5 Plays Pivotal Roles in Pathogenesis of both Metabolic Syndrome and Vascular Disease(Diabetes/Obesity/Metabolic syndrome-3 (H) OJ8,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-316 Kruppel-like family of transcription factor 5 is required for adipocyte differentiation(Diabetes/Obesity 2 (H) : OE40)(Oral Presentation (English))
- OE-097 Local Cell Dynamics and Vascular Malfunction in Obese Adipose Tissue Inflammation(Diabetes/Obesity/Metabolic syndrome(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-056 Adipogenesis and Angiogenesis in Obesity Requires Close Interplay Between Diffentiating Adipocytes, Macrophages, and Endothelial Cells(New Insights into Metabolic Syndrome(02)(H),Featured Research Session,The 72nd Annual Scientific Meeting of the
- OE-120 Close Relationships between Angiogenesis and Adipogenesis in Obesity Revealed by a Novel Visualization Technique of Living Adipose Tissue(Diabetes/Obesity/Metabolic syndrome-1 (H) OE20,Oral Presentation (English),The 70th Anniversary Annual Scienti
- OJ-512 A Zinc Finger Transcription factor δ EF1 Controls Smooth Muscle Cell Differentiation during Development and in Vascular Diseases(Vascular Smooth Muscle 2 (H) : OJ63)(Oral Presentation (Japanese))
- OE-161 Oral Retinoic Acid Receptor Alpha Agonist Inhibits In-Stent Restenosis(Restenosis after Angioplasty, Basic/Clinical 1 (IHD) : OE20)(Oral Presentation (English))
- Angiotensin II and Transforming Growth Factor Beta Induced Angiogenesis Associated Mts1 in Smooth Muscle Cells
- PPAR γ Ligand Dependent Interaction with Transcriptional Coactivators Control the Vascular Smooth Muscle Cell Differentiation
- An E-Box Binding Transcription Factor Controls Smooth Muscle Cell Differentiation Marker Genes
- Kruppel Like Zinc-Finger Trascription Factor 5 (KLF5) Madiate Immune Responses in Cardiovascular Remodeling
- Kruppel-Like Factor 5 (KLF5) and Peroxisome Proliferatesγ (PPARγ) Cooperatively Control Cellular Responses in Vascular Diseases
- 表彰論文 In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue
- PJ-610 Lysophosphatidylcholine Contributes to Insulin Resistance in Adipocytes(Diabetes/Obesity/Metabolic syndrome-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Abnormal iron deposition in the angiotensin II-induced hypertensive rats : A possible link with cardiac damage
- Mechanisms of maintenance of endothelial function by the aging-suppressor gene Klotho
- A novel pathway involving the mitogen Trichostatin A and the transcription factor IKLF/BTEB2 in regulation of the SMemb gene
- TAF-1 is a transcriptional cofactor that represses activation by the transcription factor IKLF/BTEB2
- PDGF-A chain is regulated by the transcription factor IKLF/BTEB2
- Transcriptional activation by acetylation of the transcription factor IKLF/BTEB2 by p300
- p300 activates transcription by the transcription factor IKLF/BTEB2 -implications for a role in cell-cycle arrest and differentiation
- Targeted inhibition of the transcription factor IKLF / BTEB2 results in growth arrest of smooth muscle cells
- 5 Establishment of clinical database system and identification of genetic factors contributing to the pathogenesis of atheroscherosis(Symposium 4 (SY4) (IHD) : Molecular Mechanism of Atherosclerosis)(Special Program)
- Smooth muscle-specific chromatin remodeling plays pivotal roles in transcriptional regulation during smooth muscle cell differentiation
- Interaction of multiple transcription factors controls smooth muscle-subtype-selective transcriptional regulatory modules in vivo
- Downregulation of klotho gene expression in streptozotocin-induced diabetic rats
- Am80, a Novel Synthetic RAR Agonist and a Modulator of KLF5, Prevents Cardiac Remodeling in Vivo
- Adrenomedullin Reduction Enhances Hypertrophic Response and Dysfunction of the Heart : Studies on AM Knockout Mice
- Novel Angiogenic Effects of a New HMG-CoA Reductase Inhibitor, Pitavastatin
- A Kruppel-like transcription factor IKLF/BTEB2 activates the PDGF promoter in response to angiotensin II in cardiovascular remodeling
- Insulin Receptor Substrate Deficient Mice Serve as Animal Models of Endothelial Cell Dysfunction due to Insulin Resistance
- Critical roles of IKLF/BTEB2 in vascular remodeling proved by gene targeting
- Transcriptional regulation of angiogenesis in vivo
- Angiotensin II Receptor Blockade Suppresses Downregulation of Anti-Aging Gene Expression in the Kidney of Preproteinuric Diabetic Rats(Renin-angiotensin-aldosterone System (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Endothelial PAS Domain Protein 1 (EPAS1) Regulates the Fit-1 Gene Expression in Hypoxia
- Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
- Development and Implementation of an Advanced Coronary Angiography and Intervention Database System
- Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases
- Associations of variations in the MRF2/ARID5B gene with susceptibility to type 2 diabetes in the Japanese population