Hyperpolarized ^<129>Xe MR Imaging with Balanced Steady-state Free Precession in Spontaneously Breathing Mouse Lungs

スポンサーリンク

概要

• 論文の詳細を見る

• Purpose: We investigated the characteristics of hyperpolarized (HP) 129Xe magnetic resonance (MR) imaging obtained from balanced steady-state free precession (SSFP) measurement of mouse lungs, especially under spontaneous breathing, and compared the results with those obtained using traditional spoiled gradient echo (SPGR) method, focusing on improved signal-to-noise ratio (SNR) and reduced total acquisition time. Methods: We calculated magnetization response of the HP 129Xe gas for the balanced SSFP sequence under spontaneous breathing to derive optimal conditions for the imaging experiment. We then placed an anesthetized mouse in the magnet (9.4T) supplied with oxygen gas and a mixture of HP 129Xe gas supplied from a continuous-flow hyperpolarizing system. We obtained an axial plane image of the lung through balanced SSFP and SPGR sequences, changing the various magnetic resonance (MR) imaging parameters, and measured the SNR of these images. Results: We demonstrated the clear dependence of image intensity on flip angle and number of shots. The SNR was higher in balanced SSFP than in SPGR and 2.3-fold higher compared at each maximum. In contrast, total acquisition time in balanced SSFP was shortened to about one-eighth that of SPGR using a one-shot acquisition mode. Conclusion: In HP 129Xe MR imaging of the lung of a spontaneously breathing mouse, balanced SSFP sequence with multi-shot and centric order acquisition provides higher SNR in a shorter acquisition time than SPGR.

• 日本磁気共鳴医学会の論文
• 2011-03-01

著者

• Imai Hirohiko

  Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health

• Kimura Atsuomi

  Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin

• Fujiwara Hideaki

  Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin

• Imai Fumito

  Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin

• Fujiwara Hideaki

  Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health

• Kimura Atsuomi

  Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health

• Kashiwagi Ryosuke

  Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health

• IMAI Fumito

  Division of Medical Physics and Engineering, Area of Medical Technology and Science, Course of Healt

• IGUCHI Satoshi

  Division of Medical Physics and Engineering, Area of Medical Technology and Science, Course of Healt

• Imai Fumito

  Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health

• Iguchi Satoshi

  Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health

• Fujiwara Hideaki

  Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health

• Kimura Atsuomi

  Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health

関連論文

• MR Imaging of Mouse Lung Using Hyperpolarized ^He : Image Acquisition and T_1 Estimation under Spontaneous Respiration
• A Simple Method for Quantitative Measurement and Analysis of Hyperpolarized ^Xe Uptake Dynamics in Mouse Brain under Controlled Flow
• Hyperpolarized ^Xe Phase-selective Imaging of Mouse Lung at 9.4T Using a Continuous-flow Hyperpolarizing System
• Analysis of the Temperature and Pressure Dependence of the ^Xe NMR Chemical Shift and Signal Intensity for the Derivation of Basic Parameters of Adsorption as Applied to Zeolite ZSM-5
• Analysis of Hyperpolarized ^Xe Dynamics in Mouse Lungs under Spontaneous Respiration for Separate Determination of Lung Functional Parameters and Relaxation Time
• Improvement of T_1 Determination of Hyperpolarized ^Xe in Mouse Brain under Controlled-Flow
• 3D Hyperpolarized ^Xe MRI of Mouse Lung at Low Xenon Concentration using a Continuous Flow-type Hyperpolarizing System : Feasibility for Quantitative Measurement of Regional Ventilation
• Origin of Dissolved-phase Hyperpolarized ^Xe Signal in the Mouse Chest Based on Experimental Evidence from Extensive Magnetic Resonance Measurements
• Hyperpolarized ^Xe MR Imaging with Balanced Steady-state Free Precession in Spontaneously Breathing Mouse Lungs

スポンサーリンク