A Simple Method for Quantitative Measurement and Analysis of Hyperpolarized ^<129>Xe Uptake Dynamics in Mouse Brain under Controlled Flow
スポンサーリンク
概要
- 論文の詳細を見る
We established a simple method for measuring and quantifying uptake dynamics of hyperpolarized (HP) 129Xe in mouse brain, which includes application of a saturation recovery pulse sequence under controlled flow of HP 129Xe. The technique allows pursuit of the time-dependent change in 129Xe nuclear magnetic resonance signal in the uptake process without effect from radiofrequency destruction of the polarization and the dynamics in mouse lung. The uptake behavior is well described by a simple model that depends only on a decay rate constant comprising cerebral blood flow and the longitudinal relaxation rate of HP 129Xe in the brain tissue. The improved analysis enabled precise determination of the decay rate constant as 0.107±0.013 s-1 (±standard deviation, n=5), leading to estimation of longitudinal relaxation time, T1i, as 15.3±3.5 s.
- 日本磁気共鳴医学会の論文
- 2008-12-01
著者
-
Imai Hirohiko
Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health
-
Kimura Atsuomi
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
-
Fujiwara Hideaki
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
-
KIMURA Atsuomi
Division of Medical Physics and Engineering, Area of Medical Technology and Science, Course of Healt
-
WAKAYAMA Tetsuya
Division of Medical Physics and Engineering, Area of Medical Technology and Science, Course of Healt
-
FUJIWARA Hideaki
Division of Medical Physics and Engineering, Area of Medical Technology and Science, Course of Healt
-
Fujiwara Hideaki
Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health
-
Kimura Atsuomi
Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health
-
Fujiwara Hideaki
Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health
-
Kimura Atsuomi
Division Of Medical Physics And Engineering Area Of Medical Technology And Science Course Of Health
関連論文
- MR Imaging of Mouse Lung Using Hyperpolarized ^He : Image Acquisition and T_1 Estimation under Spontaneous Respiration
- A Simple Method for Quantitative Measurement and Analysis of Hyperpolarized ^Xe Uptake Dynamics in Mouse Brain under Controlled Flow
- Hyperpolarized ^Xe Phase-selective Imaging of Mouse Lung at 9.4T Using a Continuous-flow Hyperpolarizing System
- Analysis of the Temperature and Pressure Dependence of the ^Xe NMR Chemical Shift and Signal Intensity for the Derivation of Basic Parameters of Adsorption as Applied to Zeolite ZSM-5
- Analysis of Hyperpolarized ^Xe Dynamics in Mouse Lungs under Spontaneous Respiration for Separate Determination of Lung Functional Parameters and Relaxation Time
- Improvement of T_1 Determination of Hyperpolarized ^Xe in Mouse Brain under Controlled-Flow
- 3D Hyperpolarized ^Xe MRI of Mouse Lung at Low Xenon Concentration using a Continuous Flow-type Hyperpolarizing System : Feasibility for Quantitative Measurement of Regional Ventilation
- Origin of Dissolved-phase Hyperpolarized ^Xe Signal in the Mouse Chest Based on Experimental Evidence from Extensive Magnetic Resonance Measurements
- Hyperpolarized ^Xe MR Imaging with Balanced Steady-state Free Precession in Spontaneously Breathing Mouse Lungs