Effect of Pretreatment With Pioglitazone on Reperfusion Injury in Diabetic Patients With Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
Background: Pioglitazone (PIO) is a new class of anti-diabetic agent with an anti-inflammatory effect. In the experimental studies, pretreatment with PIO before ischemia/reperfusion reduced ischemia-reperfusion injury and myocardial infarct size. However, the clinical efficacy of this therapy in patients with acute myocardial infarction (AMI) remains unknown. Methods and Results: Three hundred and nineteen diabetic patients with ST-segment elevation AMI, treated with bare metal stent within 24h from the onset of AMI were examined. Myocardial blush grade, ST-segment resolution, peak creatine kinase (CK) level, and left ventricular ejection fraction (LVEF) were compared between PIO group (pretreatment with PIO [+]; n=26) and non-PIO group (pretreatment with PIO [-]; n=293). The PIO group showed a significantly higher incidence of blush score ≥2 and complete ST-segment resolution (blush score ≥2; 38% vs. 71%, P=0.04, ST-segment resolution; 44% vs. 71%, P=0.04). Besides, slow flow/no-reflow phenomenon and reperfusion arrhythmia did not occur in this group. Better improvement of LVEF and lower peak CK level was observed in this group, although these were not statistically significant (LVEF 48% vs. 41%, P=0.10, peak CK level 2,041 vs. 3,207, P=0.06). Conclusions: Pretreatment with PIO in diabetic patients with AMI resulted in better myocardial perfusion with less reperfusion injury. (Circ J 2011; 75: 1968-1974)
- 社団法人 日本循環器学会の論文
- 2011-07-25
著者
-
Yagi Nobuhito
Division Of Cardiology National Cardiovascular Center
-
Kasahara Yoichiro
Department Of Cardiology National Cardiovascular Center
-
Kokubu Nobuaki
Division Of Cardiology National Cardiovascular Center
-
Otsuka Yoritaka
Department Of Cardiology National Cardiovascular Center
-
Otsuka Yoritaka
Department Of Cardiovascular Medicine National Cardiovascular Center
-
Kataoka Yu
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
-
Kasahara Yoichiro
Division Of Cardiology National Cardiovascular Center
-
Ohtsuka Yoritaka
Division Of Cardiology National Cardiovascular Center
-
Kokubu Nobuaki
Department Of Cardiology National Cardiovascular Center
-
Abe Mitsuru
Division Of Cardiology National Cardiovascular Center
-
Kataoka Yu
Department Of Cardiology National Cardiovascular Center
-
Abe Mitsuru
Department Of Cardiology National Cardiovascular Center
-
Ohtsuka Yoritaka
Department Of Cardiology National Cardiovascular Center
-
Kasahara Yoichiro
Department Of Cardiology National Cerebral And Cardiovascular Center
-
Yagi Nobuhito
Department Of Cardiology National Cerebral And Cardiovascular Center
-
Otsuka Yoritaka
Department Of Cardiology National Cerebral And Cardiovascular Center
-
Nagai Kouzou
Department Of Cardiology Nagai Hospital
-
Otsuka Yoritaka
Department Of Cardiology Fukuoka Wajiro Hospital
関連論文
- PJ-409 Identification of Clinical Characteristics Favorably Treated with Non-Stent Strategy for Sirolimus-Eluting Stent Restenosis : Insights from J-CYPHER Registry(PJ069,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Poster Session (Japanese
- 5 Therapeutic Strategy for Post-sirolimus-eluting Stent Restenosis and Risk Factors for Re-target Lesion Revascularization After Re-sirolimus-eluting Stent Implantation : from j-CYPHER Registry(Current Status and Future Perspective of Drug-Eluting Stents,
- PJ-409 Identification of Clinical Characteristics Favorably Treated with Non-Stent Strategy for Sirolimus-Eluting Stent Restenosis : Insights from J-CYPHER Registry(PJ069,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Poster Session (Japanese
- OJ-218 Risk Factors for Recurrent Restenosis of Post-Sirolimus-Eluting Stent Restenosis : Insights From j-CYPHER Registry(Restenosis basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
- OE-031 Sirolimus-Eluting Stent vs Balloon Angioplasty for the Treatment of Post-Sirolimus-Eluting Stent Restenosis : Insights From j-CYPHER Registry(Restenosis basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Ja
- Significant Association Between Neutrophil Aggregation in Aspirated Thrombus and Myocardial Damage in Patients With ST-Segment Elevation Acute Myocardial Infarction(Ischemic Heart Disease)
- PE-105 Significant Association between Neutrophil Aggregation in Aspirated Thrombus and Myocardial Damage in Patients with ST-segment Elevation Acute Myocardial Infarction(Acute myocardial infarction, clinical (pathophysiology)-3, The 71st Annual Scientif
- Incidence of and Risk Factors for Contrast-Induced Nephropathy After Cardiac Catheterization in Japanese Patients
- Coronary Risk Factor Profile and Prognostic Factors for Young Japanese Patients Undergoing Coronary Revascularization
- PE-141 Clopidogrel Resistance in Japanese Patients Scheduled for Percutaneous Coronary Intervention(PE024,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation S
- PJ-754 Intravascular Ultrasound Analysis of Coronary Atheroma in Patients with and without Chronic Kidney Disease following Statin Therapy from JAPAN-ACS Study(PJ127,Intravascular Imagings 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- PJ-754 Intravascular Ultrasound Analysis of Coronary Atheroma in Patients with and without Chronic Kidney Disease following Statin Therapy from JAPAN-ACS Study(PJ127,Intravascular Imagings 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- PE-105 Significant Association between Neutrophil Aggregation in Aspirated Thrombus and Myocardial Damage in Patients with ST-segment Elevation Acute Myocardial Infarction(Acute myocardial infarction, clinical (pathophysiology)-3, The 71st Annual Scientif
- PJ-754 Intravascular Ultrasound Analysis of Coronary Atheroma in Patients with and without Chronic Kidney Disease following Statin Therapy from JAPAN-ACS Study(PJ127,Intravascular Imagings 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- PE-105 Significant Association between Neutrophil Aggregation in Aspirated Thrombus and Myocardial Damage in Patients with ST-segment Elevation Acute Myocardial Infarction(Acute myocardial infarction, clinical (pathophysiology)-3, The 71st Annual Scientif
- OE-162 The Impact of CYP2C19 Polymorphism on the Antiplatelet Effect of Clopidogrel in the Real Clinical Setting(OE28,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanes
- Sirolimus-Eluting Stent for In-Stent Restenosis of Left Main Coronary Artery in Takayasu Arteritis
- Inhibition of Aldosterone Suppresses PDGF-and Basic FGF-Induced Proliferative Change in Vascular Smooth Muscle Cells
- Inhibition of Cardiac Aldosterone System by Spironolactone Blocks Gq Protein Coupled Agonist-Induced Hypertrophic Responses in Cardiac Myocytes
- Significant Association of Coronary Artery Calcification in Stent Delivery Route With Restenosis After Sirolimus-Eluting Stent Implantation
- Improved Long-Term Prognosis of Elderly Women in the Era of Sirolimus-Eluting Stents
- PJ-659 The Improvement of Long-term Prognosis of Elderly Women in the Era of the Sirolimus-Eluting Stents(PJ111,Angina Pectoris (Clinical) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 3 Effects of Anti-postprandial Hyperglycemia Drugs on the Coronary Atherosclerosis in Early Stage Diabetic Patients with Coronary Artery Disease : A Study of the DIAbetes and Diffuse Coronary NArrowing (DIANA)(Late Breaking Clinical Trials I,The 73rd Annu
- Impact of Metabolic Syndrome on the Long-Term Survival of Patients With Acute Myocardial Infarction : Potential Association With C-Reactive Protein
- Role of Transthoracic Doppler-Determined Coronary Flow Reserve in Patients With Chest Pain
- Inverted Takotsubo cardiomyopathy masking acute myocardial infarction
- DPJ-054 Is Cardiac Rehabilitation Unnecessary in Low Prognostic Risk Patients with Acute Myocardial Infarction in the Primary Intervention Era?(DPJ09,Exercise Test/Cardiac Rehabilitation (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Mee
- Angiographic and Clinical Outcomes of a Pharmacokinetic Study of Sirolimus-Eluting Stents : Lesson From Restenosis Cases
- Higher insulin level is an independent determinant in developing coronary atherosclerotic lesions in patients with impaired glucose tolerance
- Favorable outcome following percutaneous cardiopulmonary support system in patients with fluminant myocarditis : Comparison with those with acute (nonfluminant) myocarditis
- A 3-Year Clinical Outcome After Percutaneous Coronary Intervention Using Sirolimus-Eluting Stent and Off-Pump Coronary Artery Bypass Grafting for the Treatment of Diabetic Patients With Multivessel Disease
- PE-517 The Optimal Revascularization Strategy in Elderly Women with Coronary Artery Disease : Sirolimus-eluting Stent vs. Off-pump Coronary Artery Bypass Surgery(PE087,Cardiovascular Surgery/CABG (IHD),Poster Session (English),The 73rd Annual Scientific M
- OE-370 Usefulness of Mobile Telemedicine System in Real-time Transmission of Prehospital 12-lead ECG(OE63,ECG/Body Surface Potential Mapping/Holter 1 (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-693 Are There Gender Differences in Pre-hospital Delay Time Interval for Acute Myocardial Infarction?(Emergency care / CPR(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-078 Prevalence of metabolic syndrome in patients ≤45 years of age with acute myocardial infarction undergo percutaneous coronary intervention.(Diabetes/Obesity/Metabolic syndrome(09)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of
- Intravenous Administration of Nifekalant Hydrochloride for the Prevention of Ischemia-Induced Ventricular Tachyarrhythmia in Patients With Renal Failure Undergoing Hemodialysis
- Relation between Intravascular Ultrasound Findings before Intervention and Collected Debris through Distal Protection in Stable Angina or Silent Myocardial Ischemia(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 13 (IHD), The 69th Annual
- FRS-172 Decreased Serum Ghrelin Level in Patients with Acute Myocardial Infarction : Its Association with the Infarct Size and Time-dependent Recovery(Coronary Heart Disease : Basic Science (IHD) : FRS20)(Featured Research Session (English))
- PJ-659 Lesion Calcification as an Important Determinant for Coronary Restenosis after Sirolimus-eluting Stent Implantation : Calcification Score Analysis(Coronary revascularization, PCI-20 (IHD) PJ111,Poster Session (Japanese),The 70th Anniversary Annual
- PE-256 Feasibility of Transthoracic Doppler-determined Coronary Flow Reserve for the Assessment of Left Main Trunk Stenosis(Echo/Doppler-10 (I) PE43,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Societ
- OE-229 Metabolic Syndrome is a Strong Determinant of Long-term Outcomes in Patients with Acute Myocardial Infarction Underlying High C-reactive Protein Level(Acute myocardial infarction, clinical (pathophysiology)-1 (IHD) OE39,Oral Presentation (English),
- 2 Importance of Postprandial Glucose Level in the Development of Coronary Artery Disease(Treatment Strategy Update for Coronary Artery Disease with Diabetes Mellitus,Topic 8 (TP8) (IHD),The 70th Anniversary Annual Scientific Meeting of the Japanese Circul
- 1 Intracoronary Thrombus Aspiration in Patients with Acute Myocardial Infarction, Does It Make Sense?(Controversy: Clinical Significance of thrombectomy in AMI patients,Controversy 3 (C3) (IHD),The 70th Anniversary Annual Scientific Meeting of the Japanes
- 2 The Important Association between Diffuse Coronary Narrowing and Postprandial Hyperglycemia(Therapeutic strategy for the patients with coronary artery disease who show diffuse coronary artery narrowing in angiography (small vessel disease),Controversy 2
- PJ-396 Difference in Metabolic Abnormalities between Genders in Patients with First Acute Myocardial Infarction and No Previous Diagnosis of Diabetes Mellitus(Acute Myocardial Infarction, Clinical (Pathophysiology) 6 (IHD) : PJ66)(Poster Session (Japanese
- PJ-092 Assessment of Clinical Features in Slow or No Flow Phenomenon after Emergent Percutaneous Coronary Intervention(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 3 (IHD) : PJ16)(Poster Session (Japanese))
- OJ-162 Active Smoking is an Independent Risk Factor of Metabolic Syndrome in Acute Myocardial Infarction Patients via Alteration of Lipid Profile(Smoking(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Societ
- FRS-021 Contrast-Induced Nephropathy After Percutaneous Coronary Intervention is Associated With High Mortality in Patients With Chronic Kidney Disease : Insights From CREDO-Kyoto(Forefront Updates in PCI(01)(IHD),Featured Research Session,The 72nd Annual
- PJ-587 Impact of Complete Revascularization on Long-term Outcome for Diabetes Patients after Percutaneous Coronary Intervention in BMS Era : From CREDO-Kyoto Registry(Coronary revascularization, PCI-13, The 71st Annual Scientific Meeting of the Japanese C
- PJ-264 Comparison of PCI and CABG in Patients with Multi-Vessel Disease and a Prior History of Cerebrovascular Accident : From CREDO-Kyoto Study(Myocardial ischemia/reperfusion, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulat
- A Ligand for Peroxisome Proliferator-Activated Receptor Inhibits Anti-apoptotic Effects of Endothelin-1 on Cardiac Myocytes
- OJ-070 Identical Pharmacokinetics of the Sirolimus-Eluting Stent in Japanese Patients with Those in American Patients(Coronary Revascularization, PICA/Stent/DCA/Rotablator/New Device 1 (IHD) : OJ9)(Oral Presentation (Japanese))
- PE-480 Acute Renal Failure After Percutaneous Coronary Intervention is Associated with High Long-Term Mortality(Coronary revascularization, PCI-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-713 Aortic Stenosis and Acquired Type 2A Von Willebrand Syndrome : Correlation between Severity of Aortic Stenosis and Gastrointestinal Angiodysplasia (Heyde's Syndrome)(Vascular heart disease/Pericarditis/Cardiac tumor-3 (M) PJ120,Poster Session (Japa
- PJ-122 Incidence of and Risk Factors for Development of Contrast-Induced Nephropathy after Cardiac Catheterization(Preventive medicine/Epidemiology/Education-7 (H) PJ21,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
- Acute Pleuropericarditis After Coronary Stenting : A Case Report
- Efficacy and Safety of Cardiac Resynchronization Therapy with Defibrillator in Patients with Severe Heart Failure and Intraventricular Conduction Delay(Heart Failure, Clinical 9 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Administration of Recombinant Human Granulocyte-Colony Stimulating Factor Deteriorates Doxorubicin-lnduced Cardiomyopathy in Adult Mice in Vivo
- PJ-269 Is Cutting Balloon Angioplasty the Alternative Option for Focal In-stent Restenosis in DES Era?(Restenosis basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-175 Predictors of Mortality in Patients with Acute Myocardial Infarction due to Left Main Coronary Artery Occlusion(Acute myocardial infarction, clinical (diagnosis/treatment)-9, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Strategy for Angioplasty at the Stenotic Site of Coronary Anastomosis of Artery or Vein Graft(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-741 Impact of Sirolimus-Eluting Stent on Diabetic Patients with Multivessel Disease : Comparison with Bare Metal Stent and Coronary Artery Bypass Grafting(Coronary revascularization, PCI-20, The 71st Annual Scientific Meeting of the Japanese Circulatio
- 4 Improvement of Long-term Outcome in Patients with Abnormal Glucose Tolerance Who Underwent Percutaneous Coronary Intervention in the Stent Era(Symposium 7 (SY7) (IHD) : Longterm Prognosis of Japanese Patients with Coronary Disease : Medical Therapy, PCI
- Correlation Between Left Main and Carotid Artery Disease in High Risk Patients : Simultaneous Intravascular and High Resolution Ultrasound Study
- Simvastatin Activates a Zinc Finger Transcription Factor GATA-6 and Induces Differentiated Phenotype in Human Vascular Smooth Muscle Cells
- PE-458 Small Vessel and Diffuse Coronary Narrowing Developed in Patients with Impaired Glucose Tolerance : New Parameters for Assessment of Coronary Trees(Diabetes/Obesity 4 (H) : PE78)(Poster Session (English))
- OE-158 Enhanced Cardiac Production of Matrix Metalloproteinases-2 and-9 in Patients with Acute Myocardial Infarction : Its Attenuation by Statins(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 6 (IHD) : OE19)(Oral Presentation (English))
- FRS-088 Frequency and Cardioembolic Event of Patients with Left Ventricular Thrombus After Acute Myocardial Infarction(Preventive Medicine in Cardiovascular Disease (H) : FRS11)(Featured Research Session (English))
- High Blood Glucose Level at 120min of 75gOGTT Is an Independent Determinant in Developing Small Coronary Arteries
- Clinical and Pathological Features of Necropsy Cases with Ventricular Septal and Free Wall Rupture Complicating Acute Myocardial Infarction
- Local Delivery of Low-Dose ONO-4817, a Broad-Spectrum Matrix Metalloproteinase Inhibitor, Reduces Neointimal Hyperplasia Coupled with Decreased Collagen Deposition
- Local Drug Delivery for Prevention of Post-Angioplasty Restenosis
- Clinical Significance of Iodine-123-15-(p-Iodophenyl)-3-R, S-Methylpentadecanoic Acid Myocardial Scintigraphy in Patients With Aortic Valve Disease
- Drug-Eluting Stents vs Bypass Surgery for Multivessel Disease : Reply
- Ruptured Atherosclerotic Plaque Distant from Maximal Stenosis in Acute Myocardial Infarction
- Micro-CT Based Quantitative Evaluation of In Vivo Bone Regeneration with Collagen-based Biomaterials
- Efficacy of Paclitaxel-Eluting Stent in Patients With Impaired Glucose Tolerance : Comparison With Sirolimus-Eluting Stent
- Control of Wire Breakage during Wire EDM -1st Report : Monitoring of Gap Signals According to Discharged Location-
- Low Restenosis Rate After Percutaneous Revascularization of Internal Mammary Artery Graft ≤ 2.5mm in Reference Diameter
- Effect of Pretreatment With Pioglitazone on Reperfusion Injury in Diabetic Patients With Acute Myocardial Infarction
- Effects of Voglibose and Nateglinide on Glycemic Status and Coronary Atherosclerosis in Early-Stage Diabetic Patients
- Micro-CT evaluation of in vivo osteogenesis at implants processed by wire-type electric discharge machining
- Enhanced osteoblast response to electrical discharge machining surface
- Pseudoaneurysm of the Ascending Aorta With Perforation Into the Left Atrium Presenting as Acute Heart Failure
- Inappropriate Use of Oral Anticoagulants for Patients With Atrial Fibrillation:– 1-Year Outcomes of the Fushimi AF Registry –
- Current status of clinical background of patients with atrial fibrillation in a community-based survey:The Fushimi AF Registry