Ischemic Preconditioning Effect of Prodromal Angina Is Attenuated in Acute Myocardial Infarction Patients With Hypertensive Left Ventricular Hypertrophy
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概要
- 論文の詳細を見る
Background: Several animal experiments on acute myocardial infarction (AMI) have shown that the cardioprotective effects of ischemic preconditioning are more significant in hypertensive subjects. However, because there are no clinical data on the impact of hypertension on ischemic preconditioning in patients with AMI, whether clinical ischemic preconditioning of prodromal angina was beneficial in AMI patients with hypertension was investigated in the present study. Methods and Results: 125 patients with a first anterior AMI who had undergone successful reperfusion therapy were divided into 2 groups, with or without hypertension, and into 2 further subgroups based on the presence or absence of prodromal angina. Dual-isotope (thallium-201(TL)/Tc-99m pyrophosphate) single-photon emission computed tomography (SPECT) was performed within 1 week of reperfusion therapy. Left ventricular (LV) function and LV mass index (LVMI) were measured by left ventriculography and echocardiography, respectively. In patients without hypertension, prodromal angina resulted in significantly less myocardial damage on TL-SPECT, better LV ejection fraction and a greater myocardial blush grade compared to patients without prodromal angina. However, these cardioprotective effects of prodromal angina were significantly diminished in hypertensive patients. Importantly, the myocardial salvage effects of prodromal angina showed a significant negative correlation with LVMI, which was significantly greater in hypertensive patients. Conclusions: The cardioprotective effects of prodromal angina were attenuated in patients with hypertension. Hypertensive LV hypertrophy may crucially limit the effects of ischemic preconditioning in AMI. (Circ J 2011; 75: 1192-1199)
- 社団法人 日本循環器学会の論文
- 2011-04-25
著者
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竹内 利治
Cardiovascular Respiratory And Neurology Division Department Of Internal Medicine Asahikawa Medical
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Hasebe Naoyuki
旭川医科大学 循環呼吸神経病態内科学
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Kikuchi Kenjiro
旭川医科大学 内科学循環呼吸神経病態内科学
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Hasebe N
Cardiovascular Respiratory And Neurology Division Department Of Internal Medicine Asahikawa Medical
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長谷部 直幸
Department Of Crdiovascular Medicine Asahikawa Medical College
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長谷部 直幸
旭川医科大学 循環･呼吸･神経病態内科学分野
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Ishii Yoshinao
Department Of Internal Medicine Asahikawa City Hospital
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Ishii Yoshinao
Department Of Microbiology And Immunochemistry Asahikawa Medical College
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Kikuchi K
Cardiovascular Division Department Of Internal Medicine Asahikawa Medical College
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Hasebe Nayoyuki
旭川医科大学 内科学第一
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Kikuchi Kenjiro
Department Of Cardiology Hokkaido Cardiovascular Hospital
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Hasebe Naoyuki
First Department Of Internal Medicine Asahikawa Medical College And Hospital
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Takeuchi Toshiharu
First Department Of Medicine Asahikawa Medical College
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Yoshida Itsuro
Department Of Microbiology And Immunochemistry Asahikawa Medical College
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Kikuchi Kenjiro
The First Department Of Medicine (section Of Neurology) Asahikawa Medical College
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Kikuchi Kenjiro
Asahikawa Medical College
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Hasebe Naoyuki
The First Department Of Internal Medicine Asahikawa Medical College
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Kikuchi Kenjiro
First Department Of Internal Medicine. Asahikawa Medical College
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Kikuchi Kenjiro
The First Department Of Medicine
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Hasebe Naoyuki
Division Of Cardiology Respiratory Neurology Of Medicine Asahikawa Medical College
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Hasebe Naoyuki
Department Of Cardiology Asahikawa Medical College
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Kikuchi Kenjiro
Cardiovascular Division Department Of Internal Medicine Asahikawa Medical College
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Takeuchi Toshiharu
Division Of Cardiology Department Of Internal Medicine Asahikawa Medical University
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Kikuchi Kenjiro
Division Of Cardiology Department Of Internal Medicine Asahikawa Medical University
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ISHII Yoshinao
Division of Cardiology, Department of Internal Medicine, Asahikawa City Hospital
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Hasebe Naoyuki
Division Of Cardiology Department Of Internal Medicine Asahikawa Medical University
-
Ishii Yoshinao
Division Of Cardiology Department Of Internal Medicine Asahikawa City Hospital
-
Kikuchi Kenjiro
Asahiwaka Medical College
-
Takeuchi Toshiharu
First Department Of Internal Medicine Asahikawa Medical College
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竹内 利治
Division of Cardiology, Department of Internal Medicine, Asahikawa Medical University
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