Epithelial Proliferative Lesions in the Nasal Cavities of c-Ha-ras Transgenic Mice
スポンサーリンク
概要
- 論文の詳細を見る
In a study to collect background data using c-Ha-ras transgenic mice (rasH2 mice), epithelial proliferative lesions were observed in the nasal cavities of the animals with or without administration of a single intraperitoneal dose of N-methyl-N-nitrosourea (MNU). These proliferative lesions occurred most frequently in the ventral meatus of the incisive papilla (nasal cavity in the specimen). Most of the proliferative lesions were a polypoid or papillary form consisting mainly of an epithelium resembling a squamous epithelium. In addition, administration of MNU tended to increase the incidence of proliferative lesions. Therefore, in carcinogenicity studies using rasH2 mice, we may come across epithelial proliferative lesions in the nasal cavity.
- 日本毒性病理学会の論文
- 2008-09-30
著者
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Kuwasaki Emiko
Panapharm Laboratories Co. Ltd.
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Mitsuishi Mikio
Panapharm Laboratories Co. Ltd.
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Nakahara Yutaka
Panapharm Laboratories Co. Ltd.
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Nakahara Yutaka
Kumamoto Laboratory Mitsubishi Chemical Safety Institute Ltd.
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Hamamura Masao
Kumamoto Laboratory Mitsubishi Chemical Safety Institute Ltd.
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Kumabe Shino
Kumamoto Laboratory Mitsubishi Chemical Safety Institute Ltd.
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Kuwasaki Emiko
Kumamoto Laboratory Mitsubishi Chemical Safety Institute Ltd.
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KATOKU Koshirou
Kumamoto laboratory, Mitsubishi Chemical Safety Institute Ltd.
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OSHIKATA Takafumi
Kumamoto laboratory, Mitsubishi Chemical Safety Institute Ltd.
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MITSUISHI Mikio
Kumamoto laboratory, Mitsubishi Chemical Safety Institute Ltd.
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Oshikata Takafumi
Kumamoto Laboratory Mitsubishi Chemical Safety Institute Ltd.
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Mitsuishi Mikio
Kumamoto Laboratory Mitsubishi Chemical Safety Institute Ltd.
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Katoku Koshiro
Kumamoto Laboratory Mitsubishi Chemical Safety Institute Ltd.
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