Identification of Pin1-Binding Phosphorylated Proteins in the Mouse Brain

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概要

• 論文の詳細を見る

• To determine the role of Pin1 in the neurotransmission pathway, Pin1-binding proteins in mouse brain extract were identified. The Pin1-binding proteins were extracted from mouse brain homogenate, and the trypsin-digested peptides were analyzed by nano-liquid chromatography tandem mass spectrometry (LC-MS/MS). Proteins that involve the neurotransmission pathway, such as synapsin I, synapsin II, and calcium/calmodulin-dependent protein kinase type II (CaMKII), were identified in a Mascot search. Pull-down and immunoprecipitation assay indicated that Pin1 binds CaMKII in a phosphorylation-specific manner. It was assumed that Pin1 participates in the neurotransmission pathway involving the phosphorylation signal by CaMKII.

• 2010-12-23

著者

• Tatara Yota

  Laboratory Of Molecular Enzymology Graduate School Of Bioengineering Soka University

• Terakawa Takahiro

  Laboratory of Enzymology, Graduate School of Agricultural Science, Tohoku University

• Uchida Takafumi

  Laboratory Of Enzymology Department Of Molecular And Cell Biology Graduate School Of Agricultural Sc

• Uchida Takafumi

  Laboratory Of Enzymology Graduate School Of Agricultural Science Tohoku University

• Terakawa Takahiro

  Laboratory Of Enzymology Graduate School Of Agricultural Science Tohoku University

• Tatara Yota

  Laboratory Of Enzymology Graduate School Of Agricultural Science Tohoku University

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