耳下腺に生じたHER-2蛋白陽性唾液腺導管癌例

概要

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Salivary duct carcinoma (SDC), a rare aggressive salivary gland tumor with poor prognosis first described by Kleinsasser et al. in 1968, histologically resembles invasive mammary ductal carcinoma. A 68-year-old man with painful left parotid swelling and left facial nerve paralysis underwent extended total parotidectomy, ipsilateral modified neck dissection, and postoperative radiotherapy of 50 Gy. Histopathological examination showed cribriform and papillary intraductal growth and comedonecrosis, yielding a diagnosis of parotid gland SDC. Immunohistochemistry showed strong complete membrane staining for human epidermal growth factor receptor 2 (HER-2). HER-2 protein overexpression is reported to be associated with early distant breast cancer metastasis causing its dismal prognosis. Given studies correlating HER-2 protein expression with poor SDC prognosis, further studies are expected to produce biological therapy for SDC targeting this molecule.
2011-01-01