Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant
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概要
- 論文の詳細を見る
Gold nanoparticles inhibited osteoclast (OC) formation induced by the receptor activator of nuclear factor-κB ligand (RANKL) in bone marrow-derived macrophages (BMMs). This was accompanied by a decreased level of tartrate-resistant alkaline phosphatase (TRAP) and less activation of nuclear factor (NF)-κB. The nanoparticles also reduced the production of reactive oxygen species (ROS) in response to RANKL and upregulated RANKL-induced glutathione peroxidase-1 (Gpx-1), suggesting a role as an antioxidant in the BMM. The inhibitory effects on OC formation might have been due to elevated defense against oxidative stress.
- 2010-11-23
著者
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KIM Ji-Soon
School of Materials and Metallurgical Engineering, University of Ulsan
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Choi Hye-seon
Department Of Biological Sciences (bk21 Program) And Immunomodulation Research Center University Of
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Kim Jin-chun
School Of Materials Sciences And Engineering University Of Ulsan
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Kim Hye-jin
Department Of Biological Sciences (bk21 Program) And Immunomodulation Research Center University Of
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Kim Song-hee
Department Of Biological Sciences (bk21 Program) And Immunomodulation Research Center University Of
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SUL Ok-Joo
Department of Biological Sciences (BK21 Program) and Immunomodulation Research Center, University of
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KYUNG Tae-Wook
Department of Biological Sciences (BK21 Program) and Immunomodulation Research Center, University of
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KIM Youn-Young
Department of Biological Sciences (BK21 Program) and Immunomodulation Research Center, University of
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Kim Youn-young
Department Of Biological Sciences (bk21 Program) And Immunomodulation Research Center University Of
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Sul Ok-joo
Department Of Biological Sciences (bk21 Program) And Immunomodulation Research Center University Of
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Kyung Tae-wook
Department Of Biological Sciences (bk21 Program) And Immunomodulation Research Center University Of
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