Comparison with Various Parts of Broussonetia papyrifera as to the Antinociceptive and Anti-Inflammatory Activities in Rodents
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概要
- 論文の詳細を見る
This study compared the antinociceptive and anti-inflammatory effects of various parts of Broussonetia papyrifera (L.) L’Herit. ex Vent. (BP, Moraceae) by chemical-induced pain and inflammation in rodents. All BP parts (1 and 2 g/kg, p.o.) effectively inhibited writhing responses induced by 1% acetic acid. The BP radix, leaf, and fruit effectively inhibited the late-phase licking responses caused by 1% formalin. But only the BP radix and fruit reduced the edema induced by 1% carrageenan at 1–2 h. Furthermore, the BP radix reduced the abdominal Evan’s blue extravasations caused by inflammatory mediators, including serotonin and sodium nitroprusside. Finally, the radix had the highest contents of betulin and betulinic acid among all BP parts. In conclusion, the radix is the better medicinal BP part possessing antinociceptive and antiinflammatory effects, and its anti-inflammatory effects are partially related to the inhibition of vascular permeability via autocrines and nitric oxide.
- 社団法人 日本農芸化学会の論文
- 2008-09-23
著者
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Wu Chi-rei
Graduate Institute Of Chinese Pharmaceutical Sciences College Of Pharmacy China Medical University
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Lin Li-Wei
Graduate School of Nursing, Hungkuang University
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CHEN Hsin-Yu
Department of Pharmacy, Liouying, Chi-Mei Medical Center
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CHING Hui
Department of Pharmacy, Taichung Hospital, Department of Health, The Executive Yuan
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Chen Hsin-Yu
Graduate Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University
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LIAO Pen-Min
General Education Center, China Medical University
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LIN Yu-Tai
School of Pharmacy, College of Pharmacy, China Medical University
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HSIEH Ming-Tsuen
School of Pharmacy, College of Pharmacy, China Medical University
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Chen Hsin-yu
Department Of Pharmacy Liouying Chi-mei Medical Center
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LIN Li
Graduate School of Nursing, Hungkuang University
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Hsieh Ming-tsuen
School Of Pharmacy College Of Pharmacy China Medical University
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Ching Hui
Department Of Pharmacy Taichung Hospital Department Of Health
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Lin Li-wei
Graduate School Of Nursing Hungkuang University
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Wu C‐r
Graduate Institute Of Chinese Pharmaceutical Sciences College Of Pharmacy China Medical University
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Liao Pen-min
General Education Center China Medical University
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Lin Yu-tai
School Of Pharmacy College Of Pharmacy China Medical University
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