Advanced Coronary Artery Calcification and Cerebral Small Vessel Diseases in the Healthy Elderly
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概要
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Background: Coronary artery calcification (CAC) scores are widely accepted to predict risk of coronary heart diseases and are associated with atherosclerosis in other vasculatures. Cerebral small vessel diseases (SVDs), including white matter lesions (WML), silent lacunar infarction (SLI) and cerebral microbleeds (CMB), are considered to develop in conjunction with pro-atherogenic conditions, measured by CAC scores. Methods and Results: Of 672 individuals aged ≥65 years that underwent health screening, 312 subjects with brain magnetic resonance imagings (MRIs) were enrolled in this study. The distribution of baseline characteristics among individuals with or without MRIs was not different. Clinical and laboratory information was collected and CAC scores were measured using multi-detector computed tomography. Cerebral SVD were independently assessed by 2 raters who were unaware of the CAC scores. The prevalence of CAC (CAC>0) was 71.7% in men and 50.0% in women. The associations between moderate-to-extensive CAC (CAC score ≥100) and WML (adjusted odds ratio and 95% confidence interval, 4.99 and 1.33-18.73), SLI (5.04 and 1.86-13.63) and CMB (6.07 and 1.54-23.94) remained significant after adjusting for relevant confounders. Conclusions: This study documents significant associations between CAC and cerebral SVDs. The findings suggest that SVDs in the brain and CAC in the heart may develop under similar systemic pathogenic processes. (Circ J 2011; 75: 451-456)
- 2011-01-25
著者
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KIM Beom
Department of Dermatology, Seoul National University College of Medicine
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Lee Seung-Hoon
Department of Neurology, Seoul National University Hospital
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Kim Chi
Department of Neurology, Seoul National University Hospital
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Ryu Wi-Sun
Department of Neurology, Seoul National University Hospital
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Kwon Hyung-Min
Department of Neurology, SMG-SNU Boramae Medical Center
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Choi Su-Yeon
Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center
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Yoon Byung-Woo
Department of Neurology, Seoul National University Hospital
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Kim Chi
Department Of Dermatology College Of Medicine And Medical Research Institute Chungbuk National Unive
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Yoon Byung-woo
Department Of Neurology Clinical Research Institute Seoul National University Hospital
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Lee Seung-hoon
Department Of Electronic Engineering Sogang University
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Kim Beom
Department Of Chemical Engineering Konyang University
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Yoon Byung-woo
Department Of Neurology Seoul National University Hospital
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Ryu Wi-sun
Department Of Neurology Seoul National University Hospital
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Lee Seung-hoon
Department Of Neurology Seoul National University Hospital
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Choi Su-yeon
Department Of Internal Medicine Seoul National University Hospital Healthcare System Gangnam Center
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Kim Beom
Department Of Neurology Seoul National University Hospital
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Kwon Hyung-min
Department Of Neurology Smg-snu Boramae Medical Center
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Kim Chi
Department Of Neurology Seoul National University Hospital
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Choi Su-yeon
Department Of Internal Medicine Seoul National University College Of Medicine
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