Association Between Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Maintenance Hemodialysis Patients : Comparison With B-Type Natriuretic Peptide and Cardiac Troponin T

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概要

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• Background: Fibroblast growth factor 23 (FGF-23) is a novel bone-derived phosphate-regulating hormone, and serum FGF-23 levels are associated with mortality among hemodialysis (HD) patients. However, the pathophysiological role of FGF-23 in those patients remains unclear, so the association between serum FGF-23 levels and known cardiac biomarkers or echocardiographic measurements were investigated in long-term HD patients without cardiac symptoms. Methods and Results: The 87 consecutive patients treated in a single HD center (51 males, 36 females; mean age 64 years, mean HD duration 5.8 years) were included in this study. Comprehensive echocardiography was performed after HD. Blood samples were obtained before HD. Serum FGF-23 levels in dialysis patients were 1,171±553pg/ml. In univariate analysis, serum phosphate (r=0.443, P<0.001) and calcium levels (r=0.256, P=0.04), left ventricular mass index (LVMI) (r=0.268, P=0.039) were significantly associated with FGF-23 levels. Neither the B-type natriuretic peptide (BNP) nor the cardiac troponin T level was correlated with FGF-23. In multivariate regression analysis, only LVMI (β=0.287, P=0.031, confidence interval (CI) 0.390-8.040) and phosphate levels (β=0.419, P=0.001, CI 57.12-207.7) and calcium levels (β=0.277, P=0.025, CI 24.95-360.1) remained significantly correlated with FGF-23. Conclusions: Beside BNP, FGF-23 was identified as a factor that is significantly associated with LVMI. FGF-23 could be a novel biomarker of left ventricular overload, which is closely associated with the increased risk of death in HD patients. (Circ J 2010; 74: 2734-2740)

• 2010-11-25

著者

• Kurabayashi Masahiko

  Department of Medicine and Biological Science, Gunma University Graduate School of Medicine

• Takayama Yoshiaki

  Kitakanto Cardiovascular Hospital

• KASAMA Shu

  Department of Vascular Medicine, Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular

• Shimizu Takehisa

  Department of Medicine and Biological Science, Gunma university Graduate School of Medicine

• Kasama Shu

  Department Of Vascular Medicine Cardiovascular Hospital Of Central Japan (kitakanto Cardiovascular H

• Kasama Shu

  群馬県立心臓血管センター

• Kasama Shu

  Department Of Cardiovascular Medicine Gunma University School Of Medicine

• Kurabayashi M

  Department Of Medicine And Biological Science Graduate School Of Medicine Gunma University

• Negishi Kazuaki

  Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine

• Kuro-o Makoto

  University of Texas Health Science Center

• Kuroo M

  Department Of Pathology University Of Texas Southwestern Medical Center At Dallas

• Kurabayashi Masahiko

  Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine

• Kasama Shu

  Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine

• Kobayashi Mitsuru

  Hidaka Rihabilitation Hospital

• Ochiai Izuru

  Hidaka Rihabilitation Hospital

• Hasegawa Hisashi

  Pharmaceutical research labs, KIRIN Brewery Co. Ltd.

• Yamashita Takeyoshi

  Pharmaceutical research labs, KIRIN Brewery Co. Ltd.

• Kurabayashi Masahiko

  Second Department Of Internal Medicine Gunma University School Of Medicine

• Kurabayashi Masahiko

  Department Of Cardiovascular Medicine Gunma University School Of Medicine

• Kurabayashi Masahiko

  The Secound Department Of Internal Medicine

• YAMAZAKI Yuji

  Pharmaceutical Research Laboratories, Kirin Brewery Co.

• Yamagishi Takahiro

  Second Department Of Internal Medicine Gunma University School Of Medicine

• Shimizu Takehisa

  Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine

• Hasegawa Hisashi

  Pharmaceutical Research Labs Kirin Brewery Co. Ltd.

• Yamagishi Takahiro

  Second Department Of Internal Medicine Gunma University

• Yamashita Takeyoshi

  Pharmaceutical Research Laboratories Nephrology Kirin Brewery Co. Ltd.

• Kurabayashi Masahiko

  Department Of Medicine And Biological Science Graduate School Of Medicine University Of Gunma

• Kuro-o Makoto

  The Third Department Of Internal Medicine Faculty Of Medicine. University Of Tokyo

• Ochiai Izuru

  Hemodialysis Unit Hidaka Rehabilitation Hospital

• Kobayashi Mitsuru

  Hemodialysis Unit Hidaka Rehabilitation Hospital

• Hasegawa Hisashi

  Pharmaceutical Research Laboratories Kyowa Hakko Kirin Co Ltd

• Kobayashi Mitsuru

  Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine

• Kuro-o Makoto

  東京大学 第3内科

• Yamazaki Yuji

  Pharmaceutical Research Laboratories Kyowa Hakko Kirin Co Ltd

• Kurabayashi Masahiko

  Department Of Cardiology Kanazawa Medical University

• Yamazaki Yuji

  Pharmaceutical Research Laboratories Kirin Brewery Co.

• Negishi Kazuaki

  Department Of Internal Medicine And Cardiology Osaka City University School Of Medicine

• Kurabayashi Masahiko

  The Secound Of Department Of Internal Medicine Gunma Univeristy School Of Medicine.

• Shimizu Takehisa

  Department of Medicine and Biological Science

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