Controlled Production of Polymorphic Mixtures of MPPO in Batch Cooling and Drowning-Out Crystallization
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概要
- 論文の詳細を見る
To obtain a desired polymorphic composition of MPPO (4-(1-(2-(3-methoxyphenethyl)phenoxy)-3-(dimethylamino) propan-2-yloxy)-4-oxobutanoic acid), operation conditions were sought for seeded and drowning-out batch crystallization. Polymorphic mixtures having the same composition with the seed were obtained by controlling the seeding temperature, because it determined the supersaturations for the crystallization of both polymorphs. Analyzing the changes in the solution concentration and monitoring the particle behavior with FBRM, different crystallization behaviors between the polymorphs were made clear.
- 社団法人 化学工学会の論文
- 2010-07-01
著者
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Kagara Kooji
Ohara Pharmaceutical Co. Ltd.
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Nakata Yoshitaka
Ohara Pharmaceutical Co. Ltd.
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Matsuoka Masakuni
Department Of Chemical Engineering Tokyo University Of Agriculture And Technology
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KIYOSAWA Youko
OHARA Pharmaceutical Co., Ltd.
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Kiyosawa Youko
Ohara Pharmaceutical Co. Ltd.
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MATSUOKA Masakuni
Department of Chemical Engineering , Tokyo University of Agriculture and Technology
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