Update on the Role of Endothelial Lipase in High-Density Lipoprotein Metabolism, Reverse Cholesterol Transport, and Atherosclerosis
スポンサーリンク
概要
- 論文の詳細を見る
Endothelial lipase (EL) is a phospholipase that belongs to the lipoprotein lipase (LPL) family, which includes LPL and hepatic lipase (HL). Similar to LPL and HL, EL regulates lipoprotein metabolism, mainly high-density lipoprotein (HDL) metabolism and HDL cholesterol (HDL-C) levels in humans and mice. Existing data strongly suggest that inhibition of EL in humans would be expected to increase the HDL-C level. However, it has not been definitively established whether the effect of EL activity on HDL-C levels translates into effects on reverse cholesterol transport or atherosclerosis. The available data regarding the impact of EL expression and activity on HDL metabolism, reverse cholesterol transport, and atherosclerosis are reviewed. (Circ J 2010; 74: 2263-2270)
- 社団法人 日本循環器学会の論文
- 2010-10-25
著者
-
Ishida Tatsuro
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe Universit
-
Ishida Tatsuro
Division Of Cardiovascular Medicine Kobe University Graduate School Of Medicine
-
Yasuda Tomoyuki
Institute For Translational Medicine And Therapeutics And Cardiovascular Institute University Of Pen
-
RADER Daniel
Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pe
-
Rader Daniel
Institute For Translational Medicine And Therapeutics And Cardiovascular Institute University Of Pen
関連論文
- Endothelial Lipase Gene Polymorphism is Associated With Acute Myocardial Infarction, Independently of High-Density Lipoprotein-Cholesterol Levels
- Role of Endothelial Lipase in Plasma HDL levels in a Murine Model of Hypertriglyceridemia
- OE-358 Inactivation of Endothelial Lipase Increases "Good Cholesterol"(OE61,Lipid Disorders (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-343 High Glucose Stimulation Reduced Endothelial Cell-Selective Adhesion Molecule (ESAM) Expression : A Potential Role in Albuminuria in Diabetic Microangiopathy(Kidney/Renal circulation(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meetin
- Endothelial Lipase is Increased by Inflammation and Promotes LDL Uptake in Macrophages
- Targeted Inactivation of Endothelial Lipase Reduced Atherosclerosis in Apolipoprotein-E Deficient Mice(Atherosclerosis, Basic 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-064 Identification of non-secreted endothelial cell-derived lipase (EDL) isoforms in human endothelial cells(Lipid Disorders 1 (H) : OJ8)(Oral Presentation (Japanese))
- Targeted Disruption and Overexpression of Endothelial Cell-Derived Lipase Modulates Plasma HDL and LDL Cholesterol Levels
- 0677 5-HT 2A RECEPTOR T102C POLYMORPHISM IS ASSOCIATED WITH ACUTE MYOCARDIAL INFARCTION
- PE-219 Endothelial Lipase is a Key Molecule of Postprandial Hypertriglycemia in Mice(Metabolism/Biochemistry/Energetics(02)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-155 RAGE Deficiency Inhibit the Atherosclerosis Progression in non diabetic Low-Density Lipoprotein Receptor Knockout Mice(Atherosclerosis, basic(04)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- P495 MOLECULAR ANALYSIS OF SEROTONIN (5-HYDROXY-TRYPTAMINE; 5-HT) RECEPTOR SUBTYPES IN HUMAN CORONARY ARTERIES
- 0683 THE N-TERMINAL MYRISTOYLATION IS IMPORTANT FOR STRETCH-INDUCED ACTIVATION OF ENDOTHELIAL CELL NITRIC OXIDE SYNTHASE
- P194 Serotonin-mediated regulation of 5-HT2A receptor mRNA via activation of protein kinase C in vascular smooth muscle cells
- -1344- MOLECULAR ANALYSIS OF 5-HYDROXYTRIPTAMINE RECEPTORS IN HUMAN CORONARY ARTERIES(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Oxidative lipoprotein and lysophosphatidylcholine upregulate cNOS mRNA expression in bovine aortic endothelial cells
- PE-457 Endothelial Lipase is Increased by Inflammation and Promotes LDL Uptake in Macrophages(Infection/Inflammation/Immunity-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-207 Endothelial lipase selectively regulates HDL metabolism in rabbits(Lipid disorders(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-175 Role of Endothelial Cell-selective Adhesion Molecule (ESAM) in Tumor Angiogenesis and Metastasis(Molecular biology, vascular(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- -P605- Coronary Artery Wall Characteristics of Spastic Sites in Patients With Vasospastic Angina Assessed by Intravascular Ultrasound - Comparison Between Acetylcholine- and Serotonin- induced Coronary Spasm(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETI
- -0432- Relationshiop Between Morphology of Coronary Artery and Serum Cholesterol Value in Patients with Ischemic Heart Disease Assessed by Intravascular Ultrasound.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Angiographic Analysis of Spastic Sites Where Serotonin and Acetylcholine Provoked Coronary Vasospasms
- Oxidized LDL and Unsaturated Fatty Acids Inhibit Receptor-Mediated Ca^ Mobilization in Cultured Endothelial Cells
- Role of Endothelial Cell-Derived Lipase in Monocyte Adhesion to Endothelial Cells
- Update on the Role of Endothelial Lipase in High-Density Lipoprotein Metabolism, Reverse Cholesterol Transport, and Atherosclerosis
- PJ-666 EL Overexpression in the Vessel Wall doesn't Affect Atherosclerotic Lesion Formation in ApoE-KO mice(Molecular biology, vascular-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-113 Over-expression of Endothelial Lipase in the Liver Exacerbated Hepatic Steatosis in a Mouse Model of Metabolic Syndrome(Diabetes/Obesity/Metabolic syndrome-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-042 Targeted Inactivation of Endothelial Cell-selective Adhesion Molecule Inhibits Susceptibility to Atherosclerosis in Apoprotein-E-deficient Mice(Vascular Biology in Endothelial Cells (basic), The 71st Annual Scientific Meeting of the Japanese Circu
- 3 The Role of Endothelial Lipase in HDL Metabolism and Atherosclerosis : A New Therapeutic Target for Raising HDL-Cholesterol(Hypoalphalipoproteinemia, Its Pathogenesis and Treatments, The 71st Annual Scientific Meeting of the Japanese Circulation Society
- PJ-241 A Sandwich Enzyme-linked Immunosorbent Assay for Human Endothelial Lipase Concentration(Lipid disorders-3 (H) PJ41,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-076 Endothelial Lipase-Deficient Mice are Protected Against Lipopolysaccharide-Induced Cardiac Inflammation and Left Ventricular Dysfunction(Infection/Inflammation/Immunity-1 (H) OE13,Oral Presentation (English),The 70th Anniversary Annual Scientific M
- OE-058 Endothelial Lipase is Responsible for the Low Selrum HDL Level in the Chemically Induced Murine Model of Hyperlipidemia(Lipid disorders-1 (H) OE10,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulatio
- Endothelial Lipase Overexpression Accelerates Lesion Formation in Mouse Model of Vascular Remodeling (Molecular Biology, Vascular 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Targeted Disruption of Endothelial Lipase Reduced Susceptibility to Mortality in Endotoxin Shock(Infection/Inflammation/Immunity 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Impact of Cytochrome P450 2C19^*2 Polymorphism on Intra-Stent Thrombus After Drug Eluting Stent Implantation in Japanese Patients Receiving Clopidogrel
- Endothelial cell-selective adhesion molecule modulates atherosclerosis through plaque angiogenesis and monocyte-endothelial interaction
- Identification of Biomarkers of Stent Restenosis With Serum Metabolomic Profiling Using Gas Chromatography/Mass Spectrometry
- Isolated Primary Cardiac Sarcoidosis Presenting as Acute Heart Failure