皮膚微小循環血流計測装置の開発とその生体応用
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概要
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Dermal circulation is affected by age, changes in the environmental conditions, and diseases. To measure the dermal circulation, laser Doppler flowmeters (LDF) are used in the clinical and research fields, but there are problems; for example, evaluation of blood circulation in the whole tissues is difficult because the probe (PB) has to be fixed at a site of the skin. In this study, to solve these problems, we attempted to develop a new flowmeter, and evaluated basic data and its clinical application.We developed a contact type LDF equipped with a thermal loading device, and evaluated its clinical application. In the PB of this apparatus, 7 transmission and reception fiber units (FU) were arranged on the measurement surface with a diameter of 16 mm, and integrated with the heating and cooling Pertiers elements, by which temperature in the flowmeter can be controlled, and fluctuations of blood flow signals were averaged.To evaluate dermal vasomotor function using this apparatus, several sites in 10 healthy females in their 20s were transiently (2min) cooled (10°C), and changes in the blood circulation were measured before, during, and after the cooling period.Nine parameters, such as the mean blood flow when the dermal surface was maintained at 30°C for 1 min (F30°C) and the minimal blood flow when the dermal surface was maintained at 10°C for 2min (Fmin), were used for analysis, and the dermal microcirculation was classified into types A (in the palms), B (in the cheeks), and C (in the forearms). The results agreed well with the known distribution of blood vessels and density of nerves.We developed a contact type 64-channel two-dimensional laser Doppler flowmeter (64-Ch LDF), and evaluated its clinical application. To measure the two-dimensional changes in the blood flow in a fixed dermal region, we developed a 64-Ch LDF equipped with a contact type PB, in which 64FU were arranged to form an 8×8 matrix at intervals of 2mm.To evaluate the clinical application of this apparatus, the hemodynamic changes caused by Valsalvas treatment of microcirculation on the palm were examined. It was found that the distribution of blood flow in the measurement region changed with the physiological treatment, indicating that this apparatus was useful for the evaluation of hemodynamics.In the future, we will perform clinical studies of vascular diseases and studies on microcirculation improving drugs, and our apparatus will provide a new evaluation method.
- 2005-01-25
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