Coenzyme Q10 Attenuated DMH-Induced Precancerous Lesions in SD Rats

スポンサーリンク

概要

• 論文の詳細を見る

• Coenzyme Q10 (CoQ10) is known to be a compound with mitochondrial bioenergetic functions and antioxidant activity. In this study, we evaluated the effect of CoQ10 on the formation of aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH), DMH-induced leukocytic DNA damage and gene expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) by real-time PCR in colonic mucosa of male SD rats. The animals were divided into three groups and fed a casein-based high-fat and low fiber diet (100 g lard+20 g cellulose/kg diet) with or without CoQ10 (0.4 mg in soybean oil/kg BW/d, i.p.). One week after beginning the diets, the rats were subjected to 6 wk of treatment with DMH (30 mg/kg/wk, s.c.) and CoQ10 treatments continued over the entirety of the experimental period (59 d). Administration of CoQ10 resulted in reduction of ACF numbers, to 20% of the carcinogen control value. CoQ10 supplementation induced an antigenotoxic effect on DMH-induced DNA damage in the blood cells. Colonic mucosa of DMH-injected rats had significantly greater COX-2 and iNOS gene expression than those of control rats, while treatment with CoQ10 induced an inhibitory effect on over-expression of COX-2 and iNOS in colon tumors. Our results provide evidence that CoQ10 has a protective effect on the process of colon carcinogenesis, suppressing the development of preneoplastic lesions, possibly by modulating COX-2 and iNOS gene expression in colonic mucosa and DNA damage in leukocytes, suggesting that CoQ10 has chemotherapeutic activity.

• 2010-04-01

著者

• Kim Jung-mi

  Department Of Food And Nutrition Kyungnam University

• Park Eunju

  Department Of Food And Nutrition Kyungnam University

関連論文

• Coenzyme Q10 Attenuated DMH-Induced Precancerous Lesions in SD Rats
• A Probiotic Strain of Bacillus polyfermenticus Reduces DMH Induced Precancerous Lesions in F344 Male Rat(Miscellaneous)
• Effect of Heat Treatment on the Antioxidative and Antigenotoxic Activity of Extracts from Persimmon (Diospyros kaki L.) Peel
• Soy Isoflavone Supplementation Alleviates Oxidative Stress and Improves Systolic Blood Pressure in Male Spontaneously Hypertensive Rats
• Effects of Puffer (Sphoeroides rubripes) Supplementation on Disruption of Antioxidant Defense Systems in Ethanol-Treated Rats
• Antioxidant Activity and Fatty Acid Composition of Four Different Persimmon Seeds
• Effects of Bacillus polyfermenticus SCD on Lipid and Antioxidant Metabolisms in Rats Fed a High-Fat and High-Cholesterol Diet(Miscellaneous)
• Whey Protein Inhibits Iron Overload-Induced Oxidative Stress in Rats

スポンサーリンク