ENU induced single mutation locus on chr 16 leads to high-frequency hearing loss in mice
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概要
- 論文の詳細を見る
The hallmark of age-related (presbycusis) and noise-induced hearing loss is high-frequency (> 20 kHz) hearing loss. Through a collaborative study with TMGC (Tennessee Mouse Genome Consortium), seventeen ENU-induced mouse mutation strains with high-frequency hearing loss have been identified, but affected genes are yet identified. As a first step in identifying the gene/s underlying the ENU mutations, we created a F2 population between a representative mutation strain, 118 TNE and a wild type strain, CAST/EJ (CAST). Phenotypic analysis showed that there is a 3:1 ratio of segregation between normal and hearing loss in the F2 population, suggestion a single locus regulation. However, the linkage mapping identified 2 QTLs, each on chromosomes 15 and 16. Further statistical analysis of marker segregation patterns revealed that the locus on Chr 16 was ENU induced while the one on Chr 15 was derived from the parental strain, CAST.
- 2009-06-25
著者
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JIAO Yan
Departments of Orthopaedic Surgery-Campbell Clinic and Pathology, University of Tennessee Health Sci
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CAI Chun
Departments of Medicine, University of Tennessee Health Science Center (UTHSC)
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KERMANY Mohammad
Departments of Medicine, University of Tennessee Health Science Center (UTHSC)
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YAN Jian
Departments of Orthopaedic Surgery-Campbell Clinic and Pathology, University of Tennessee Health Sci
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CAI Qing
Departments of Medicine, University of Tennessee Health Science Center (UTHSC)
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MILLER Darla
Mammalian Genetics & Genomics, Oak Ridge National Laboratory
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GOLDOWITZ Daniel
Centre for Molecular Medicine and Therapeutics, Dept Medical Genetics, University of British Columbi
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LI Xinmin
UCLA Clinical Microarray Core, Department of Pathology & Laboratory Medicine, University of Californ
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YOO Tai-June
Departments of Medicine, University of Tennessee Health Science Center (UTHSC)
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GU Weikuan
Departments of Orthopaedic Surgery-Campbell Clinic and Pathology, University of Tennessee Health Sci
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Cai Chun
Departments Of Medicine University Of Tennessee Health Science Center (uthsc)
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Jiao Yan
Departments Of Orthopaedic Surgery-campbell Clinic And Pathology University Of Tennessee Health Scie
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Cai Qing
Departments Of Medicine University Of Tennessee Health Science Center (uthsc)
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Cai Qing
Department Of Infectious Disease Airforce General Hospital Of People's Liberation Army
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Li Xinmin
Ucla Clinical Microarray Core Department Of Pathology & Laboratory Medicine University Of Califo
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Gu Weikuan
Departments Of Orthopaedic Surgery-campbell Clinic And Pathology University Of Tennessee Health Scie
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Miller Darla
Mammalian Genetics & Genomics Oak Ridge National Laboratory
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Yoo Tai-june
Departments Of Medicine University Of Tennessee Health Science Center (uthsc)
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Kermany Mohammad
Departments Of Medicine University Of Tennessee Health Science Center (uthsc)
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Goldowitz Daniel
Centre For Molecular Medicine And Therapeutics Dept Medical Genetics University Of British Columbia
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Gu Weikuan
Department Of Orthopaedic Surgery-campbell Clinic And Pathology University Of Tennessee Health Science Center (uthsc)
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Jiao Yan
Department Of Medicine University Of Tennessee Health Science Center
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Cao Yanhong
Institute Of Kaschin-beck Disease Center For Endemic Disease Control Centers For Disease Control And Prevention Harbin Medical University
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Habiby Kermany
Departments of Medicine, University of Tennessee Health Science Center (UTHSC)
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