Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations
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概要
- 論文の詳細を見る
Although the intracellular de novo synthesis of the polyamines decreases with age, there is no similar trend in blood polyamine levels, but rather there is wide individual variability. We hypothesized that dietary polyamines attenuate a decrease in blood polyamine levels with age and augment the previously observed individual variability. The effect of a polyamine rich diet, in both mice and humans, on blood polyamine concentrations was examined in this study. Jc1:ICR male mice were fed test diets containing 3 different polyamine concentrations. Healthy human male volunteers added 50 to 100 g of the polyamine-rich fermented soybean product, natto, to their daily intake. After 26 wk, the mean blood spermine concentration in mice receiving the test diet with high polyamine concentrations was 10.1±2.4 μmol/L, while the mean concentrations found in mice fed with a diet with normal or low polyamine concentrations were 5.2±0.9 and 4.7±0.5 μmol/L, respectively (p<0.05). A mean daily intake of 66.4±3.7 g (range=46.4-89.3 g) of natto for 2 mo by human volunteers increased the mean blood spermine concentration by a factor of 1.39 (n=10) (p<0.01), while in control volunteers (n=7), asked to exclude polyamine-rich foods from their diet, blood spermine concentration remained unchanged. The individual variability of blood polyamine levels was enhanced after polyamine intake in mice and, to a lesser extent, in humans. The long-term oral intake of enhanced polyamine diets increases blood polyamine levels in both mice and humans.
- 財団法人 学会誌刊行センターの論文
- 2009-08-01
著者
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KONISHI FUMIO
Department of Surgery, Jichi Medical School Omiya Medical Center
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Lefor Alan
Department Of Surgery Jichi Medical University
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Lefor Alan
Department Of Surgery Saitama Medical Center Jichi Medical University
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Takao Koichi
Laboratory Of Cellular Physiology Department Of Clinical Dietetics & Human Nutrition Faculty Of
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KANO Yoshihiko
Department of Biolology, Faculty of Science, Shizuoka University
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SODA Kuniyasu
Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University
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SAKURAGI Masako
Department of Surgery, Saitama Medical Center, Jichi Medical University
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Soda Kuniyasu
Cardiovascular Research Institute Saitama Medical Center Jichi Medical University
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Kano Yoshihiko
Department Of Surgery Saitama Medical Center Jichi Medical University
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Konishi Fumio
Department Of Surgery Jichi Medical School
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Sakuragi Masako
Department Of Surgery Saitama Medical Center Jichi Medical University
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Konishi Fumio
Department Of Surgery Iichi Medical School
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Lefor Alan
Department Of Gastroenterological And General Surgery Division Of Endoscopic Surgery Medical Simulation Center The Center For Graduate Medical Education Jichi Medical University
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