Effect of N-acetylcysteine on ^<12>C^<6+> ion Irradiation-induced Lymphocytes DNA Damages and Immunity Changes in Mice
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概要
- 論文の詳細を見る
The aims of present study are to estimate the biological risks to the immunity of mice exposed to heavy ion radiation and to investigate the effect of N-acetylcysteine (NAC) on 12C6+ ion irradiation-induced lymphocyte DNA damage. Results showed that in the brine group, the levels of lymphocyte DNA damage and MN, thymocytes G2/M phase arrest and apoptosis percentages (except for activity of NK cells) were up at each time point. A time-response curve for MN and DNA damage appeared in the NAC group. We found that whole-body 12C6+ ion irradiation at a dose of 4 Gy could: induce lymphocyte DNA double-strand breaks (DSBs); immunocytes DSBs may lead to acute effects on immunity; and 200 mg/kg NAC showed significant protection against radiation harm.
- 日本放射線影響学会の論文
- 2009-11-16
著者
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Xie Yi
Research Center For Heavy Ion Radiation Biology And Medicine Institute Of Modern Physics Chinese Aca
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Hao Jifang
Research Center For Heavy Ion Radiation Biology And Medicine Institute Of Modern Physics Chinese Aca
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Zhang Hong
Research Center For Heavy Ion Radiation Biology And Medicine Institute Of Modern Physics Chinese Aca
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HAO Ji-Fang
Research Center for Heavy Ion Radiation Biology and Medicine, Institute of Modern Physics, Chinese A
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QIU Rong
Research Center for Heavy Ion Radiation Biology and Medicine, Institute of Modern Physics, Chinese A
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Qiu Rong
Research Center For Heavy Ion Radiation Biology And Medicine Institute Of Modern Physics Chinese Aca
関連論文
- Effect of N-acetylcysteine on ^C^ ion Irradiation-induced Lymphocytes DNA Damages and Immunity Changes in Mice
- Adenovirus-mediated p53 gene transfer sensitizes hepatocellular carcinoma cells to heavy-ion radiation
- Germ Cell Loss Induced by ^C^ Ion Irradiation in Young Female Mice