Acemannan Stimulates Gingival Fibroblast Proliferation ; Expressions of Keratinocyte Growth Factor-1, Vascular Endothelial Growth Factor, and Type I Collagen ; and Wound Healing

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概要

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• <i>Aloe vera</i> has long been used as a traditional medicine for inducing wound healing. Gingival fibroblasts (GFs) play an important role in oral wound healing. In this study, we investigated the effects of acemannan, a polysaccharide extracted from <i>Aloe vera</i> gel, on GF proliferation; keratinocyte growth factor-1 (KGF-1), vascular endothelial growth factor (VEGF), and type I collagen production; and oral wound healing in rats. [³H]-Thymidine incorporation assay and ELISA were used. Punch biopsy wounds were created at the hard palate of male Sprague Dawley rats. All treatments (normal saline; 0.1% triamcinolone acetonide; plain 1% Carbopol^¨; and Carbopol^¨ containing 0.5%, 1%, and 2% acemannan (w/w)) were applied daily. Wounded areas and histological features were observed at day 7 after treatment. From our studies, acemannan at concentrations of 2, 4, 8, and 16 mg/ml significantly induced cell proliferation (<i>P</i>

• 2009-04-20

著者

• Sangvanich Polkit

  Department Of Chemistry Faculty Of Science Chulalongkorn University

• BANLUNARA Wijit

  Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University

• Jettanacheawchankit Suwimon

  Oral Biology Program, Faculty of Dentistry, Chulalongkorn University

• Sasithanasate Siriruk

  Veterinary Pathobiology Program, Faculty of Veterinary Science, Chulalongkorn University

• THUNYAKITPISAL Pasutha

  Department of Anatomy, Faculty of Dentistry, Chulalongkorn University

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